Deflux 10 mg (Tablet)

Unit Price: ৳ 4.00 (10 x 15: ৳ 600.00)
Strip Price: ৳ 60.00

Medicine Details

Category Details
Generic Domperidone maleate
Company Beximco pharmaceuticals ltd
Also available as
Deflux meltab 10 mg tablet Deflux 5 mg suspension Deflux 5 mg pediatric drop

Title

  • Deflux 10 mg Tablet

Categories

  • Medicine
  • Pharmaceuticals

Description

Domperidone is a dopamine antagonist used to treat dyspeptic symptom complex, acute nausea and vomiting, Parkinson's disease, and speeding barium transit in follow-through radiological studies.

Color Options

  • White

Functions

  • Relieves nausea
  • Relieves vomiting
  • Enhances gastric emptying
  • Regulates contraction of the pylorus
  • Increases esophageal peristalsis
  • Regulates lower esophageal sphincter pressure

Material

  • Domperidone

Technical Specifications

  • Molecular Formula: C22H24ClN5O2
  • Chemical Structure: https://medex.com.bd/storage/res/g-res-380-domperidone-maleate-chemical-structure-4Q6P0Z8laWrV7xnOkSMm.svg

Usability Features

  • To be taken before meals
  • Contraindicated in neonates
  • Caution in patients with hepatic impairment or renal insufficiency

Dosage & Administration

  • Adults:
    • 10-20 mg (1-2 tablet or 10-20 ml suspension), every 6-8 hours daily
  • Children:
    • 2-4 ml suspension/10 kg body weight or 0.4-0.8 ml pediatric drops/10 kg body weight, every 6-8 hours daily

Interactions

  • Antagonizes with anticholinergic drugs
  • Lowered bioavailability with antacids and antisecretory drugs
  • Metabolized through CYP3A4
  • May influence absorption of concomitantly orally administered drugs
  • Does not potentiate neuroleptics
  • Suppresses unwanted peripheral effects of dopaminergic agonists

Contraindications

  • Known hypersensitivity
  • Neonates
  • Gastrointestinal hemorrhage
  • Mechanical obstruction or perforation
  • Prolactin releasing pituitary tumor (prolactinoma)

Side Effects

  • Transient intestinal cramps
  • Extrapyramidal phenomena
  • Increase in plasma prolactin level
  • Allergic reactions such as rash and urticaria

Pregnancy & Lactation

  • Pregnancy: Use during first trimester if justified by therapeutic benefit
  • Lactation: Use with caution, nursing not recommended unless benefits outweigh potential risks

Precautions & Warnings

  • Caution in children due to risk of extra-pyramidal reactions
  • Caution in patients with hepatic impairment

Use in Special Populations

  • Caution in infants due to incomplete development of blood-brain barrier
  • Caution in patients with liver disorders
  • Caution in patients with severe renal insufficiency

Overdose Effects

  • Drowsiness
  • Disorientation
  • Extrapyramidal reactions
  • Recommendation: Activated charcoal, close observation, use of anticholinergic, antiparkinson drugs or antihistamines

Therapeutic Class

  • Motility Stimulants
  • Dopamine antagonist
  • Prokinetic drugs

Storage Conditions

Store below 30°C, protected from light & moisture, keep out of children's reach

Commonly Asked Questions

  • Used for relieving nausea, vomiting, and indigestion
  • Caution with alcohol consumption
  • Potential side effects: dizziness, sleepiness, dry mouth, watery diarrhea, fever, or stomach pain

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