Ketmine 50 mg/ml (IM/IV Injection)

Indications

• Anesthetic agent for diagnostic procedures
• Anesthetic agent for surgical procedures
• Short procedure suitability
• Use for longer procedures with additional doses
• Debridement and painful dressings in burn patients
• Neurodiagnostic procedures
• Diagnostic and operative procedures for eye, ear, nose, and mouth
• Induction of anesthesia prior to administration of other agents
• Supplement for low-potency agents

Pharmacology

• Rapid-acting nonbarbiturate general anesthetic
• Produces analgesic state
• Characterized by dissociative anesthesia
• Hypnotic effects
• Analgesic effects
• Amnesic effects

Dosage & Administration

• Onset of action within 30 seconds (IV)
• Surgical anesthesia within 5-10 minutes (IV)
• Intramuscular surgical anesthesia within 12-25 minutes
• Initial intravenous dose of 1-4.5mg/kg
• Maintenance doses may be repeated as needed
• Recommended slow administration over 60 seconds
• May be administered intramuscularly

Interaction

• Prolonged recovery with concurrent use of barbiturates/narcotics
• Clinically compatible with general and local anesthetic agents

Contraindications

• Significant elevation of blood pressure
• Hypersensitivity to the drug

Side Effects

• Elevated blood pressure and pulse rate
• Possible hypotension and bradycardia
• Potential respiratory depression or apnea
• Diplopia and nystagmus
• Enhanced skeletal muscle tone
• Possible anorexia, nausea, and vomiting

Pregnancy & Lactation

• Not recommended in pregnancy or lactation

Precautions & Warnings

• Use by experienced physicians
• Active pharyngeal and laryngeal reflexes
• Avoid use alone in surgery of pharynx, larynx, or bronchial tree
• Avoid mechanical stimulation of pharynx
• Administer intravenous dose over 60 seconds

Overdose Effects

• Possible respiratory depression
• Supportive ventilation may be required
• Wide margin of safety
• Unintentional administration of overdoses have been followed by prolonged but complete recovery

Therapeutic Class

• General (Intravenous) anesthetics

Storage Conditions

• Store in a cool dry place
• Protect from light
• Keep out of reach of children

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