Deflux Meltab 10 mg (Dispersible Tablet)

Unit Price: ৳ 3.50 (10 x 10: ৳ 350.00)
Strip Price: ৳ 35.00

Medicine Details

Category Details
Generic Domperidone maleate
Company Beximco pharmaceuticals ltd
Also available as
Deflux 10 mg tablet Deflux 5 mg suspension Deflux 5 mg pediatric drop

Indications

  • Dyspeptic symptom complex
  • Delayed gastric emptying
  • Gastroesophageal reflux
  • Esophagitis
  • Acute nausea and vomiting
  • Functional nausea and vomiting
  • Radiological studies

Pharmacology

  • Dopamine antagonist
  • ChemoreceptorTrigger Zone (CTZ) blocker
  • Gastroprokinetic action
  • Weak penetration of blood-brain barrier
  • Restores normal motility and tone of upper gastrointestinal tract
  • Facilitates gastric emptying
  • Enhances antral and duodenal peristalsis

Dosage & Administration

  • Should be taken 15-30 minutes before meals
  • Oral dose for Adults: 10-20 mg every 6-8 hours daily
  • Oral dose for Children: 2-4 ml suspension/10 kg body weight every 6-8 hours daily
  • Rectal dose for Adults: 30-60 mg every 4-8 hours
  • Maximum dose of 80 mg daily
  • Maximum period of treatment is 12 weeks

Interaction

  • Anticholinergic drugs antagonize effect
  • Antacids and antisecretory drugs lower oral bioavailability
  • Main metabolic pathway through CYP3A4
  • In vitro use of drugs that significantly inhibit CYP3A4
  • Potential influence on absorption of orally administered drugs
  • No influence on neuroleptics

Contraindications

  • Known hypersensitivity to the drug
  • Neonates
  • Gastrointestinal hemorrhage
  • Mechanical obstruction or perforation
  • Prolactin releasing pituitary tumor (prolactinoma)

Side Effects

  • Transient intestinal cramps
  • Rare extrapyramidal phenomena in young children and adults
  • Increase in plasma prolactin level
  • Neuroendocrinological phenomena in rare cases
  • Rare allergic reactions such as rash and urticaria

Pregnancy & Lactation

  • Use only during the first trimester if justified by therapeutic benefit
  • No evidence of increased risk of malformations in humans
  • Excreted in breast milk at lower concentrations than plasma
  • Nursing not recommended unless expected benefits outweigh potential risk

Precautions & Warnings

  • Caution in children due to risk of extra-pyramidal reactions
  • Caution in patients with hepatic impairment

Use in Special Populations

  • Caution in infants due to immature blood-brain barrier
  • Caution in patients with hepatic impairment
  • Dose adjustments in patients with severe renal insufficiency
  • Regular reviews for patients on prolonged therapy

Overdose Effects

  • Symptoms may include drowsiness, disorientation, and extrapyramidal reactions
  • Administration of activated charcoal recommended
  • Anticholinergic, antiparkinson drugs may be helpful in controlling extrapyramidal reactions

Therapeutic Class

  • Motility Stimulants
  • Dopamine antagonist
  • Prokinetic drugs

Storage Conditions

  • Store below 30°C
  • Protected from light and moisture
  • Keep out of children's reach

Chemical Structure

  • Molecular Formula: C22H24ClN5O2

Common Questions about Deflux Meltab 10 mg Tablet

  • Used to treat nausea and vomiting
  • Helps relieve nausea, vomiting, and indigestion
  • Should be taken before meals as per doctor's prescription
  • May cause dizziness and sleepiness
  • Avoid consuming alcohol when taking
  • Inform doctor if watery diarrhea, fever, or stomach pain persists

Related Brands