G-Thiopentone 500 mg/vial (IV Injection)

Indications

• Sole anesthetic agent for brief procedures
• Induction of anesthesia prior to administration of other anesthetic agents
• Supplement to regional anesthesia
• Hypnosis during balanced anesthesia with other agents for analgesia or muscle relaxation

Composition

• Thiopental 500 mg injection
• Thiopental 1 gm injection
• Each vial contains Thiopental Sodium and anhydrous Sodium Carbonate
• Each box contains Water for Injection ampoules

Pharmacology

• Ultrashort-acting depressant of the central nervous system
• Induces hypnosis and anesthesia, but not analgesia
• Binds at a distinct binding site associated with a Cl-ionopore at the GABAA receptor

Dosage & Administration

• Administered intravenously as a 2.5% w/v solution
• Premedication usually consists of atropine or scopolamine
• Recommended test dose of 25 mg to 75 mg to assess tolerance
• Normal dosage for induction of anesthesia is 100 mg to 150 mg injected over 10 to 15 seconds

Interaction

• Possible increase in difficulty in producing anesthesia in patients taking alcohol or CNS depressants
• Additive action with other CNS depressants including sedatives, hypnotics, nitrous oxide or alcohol

Contraindications

• Absolute contraindications: absence of suitable veins for intravenous administration, hypersensitivity to barbiturates

Side Effects

• Hypersensitivity reactions
• Respiratory depression
• Myocardial depression
• Cardiac arrhythmias

Pregnancy & Lactation

• Pregnancy Category C
• Not known whether Thiopental can cause fetal harm when administered to a pregnant woman

Precautions & Warnings

• G-Thiopentone may be habit forming
• G-Thiopentone for Injection should be administered with caution in patients with preexisting hypotension

Overdose Effects

• Too rapid injection may lead to an alarming fall in blood pressure
• Apnea
• Laryngospasm

Therapeutic Class

• Intravenous anesthetics

Storage Conditions

• Store at controlled room temperature of 15°C to 30°C
• Solutions should be freshly prepared and used immediately

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