Thiopen 500 mg/vial (IV Injection)

Indications

• As the sole anesthetic agent for brief (15 minutes) procedures
• For induction of anesthesia prior to administration of other anesthetic agents
• To supplement regional anesthesia
• To provide hypnosis during balanced anesthesia with other agents for analgesia or muscle relaxation
• For the control of convulsive states during or following inhalation anesthesia, local anesthesia, or other causes
• In neurosurgical patients with increased intracranial pressure
• For narcoanalysis and narcosynthesis in psychiatric disorders

Composition

• Thiopental 500 mg injection
• Thiopental 1 gm injection

Pharmacology

• Induces hypnosis and anesthesia
• Ultrashort-acting depressant of the central nervous system
• Binds at a distinct binding site associated with a Cl^- ionopore at the GABA_A receptor

Dosage & Administration

• Administered intravenously normally as a 2.5% w/v solution
• Test dose of 25 mg to 75 mg to assess tolerance
• Normal dosage for induction of anesthesia is 100 mg to 150 mg injected over 10 to 15 seconds
• Dosage varies for adults, children, and elderly patients
• Use in convulsive states: 75 mg to 125 mg should be given as soon as possible after the convulsion begins

Interaction

• Possible increase in difficulty in producing anaesthesia in patients taking alcohol or CNS depressants
• Additive action with other CNS depressants including sedatives, hypnotics, nitrous oxide, or alcohol
• Increased hypotension and excitatory effects with phenothiazine antipsychotics

Contraindications

• Absence of suitable veins for intravenous administration
• Hypersensitivity (allergy) to barbiturates
• Variegate porphyria (South African) or acute intermittent porphyria
• Status asthmaticus
• Severe cardiovascular disease
• Hypotension or shock

Side Effects

• Hypersensitivity reactions
• Respiratory depression
• Myocardial depression
• Cardiac arrhythmias
• Hypotension
• Tachycardia
• Sneezing
• Coughing
• Bronchospasm
• Laryngospasm
• Shivering
• Anaphylactic reactions

Pregnancy & Lactation

• Pregnancy Category C
• Thiopental readily crosses the placental barrier and may appear in the milk of nursing mothers following administration of large doses

Precautions & Warnings

• A person competent in anesthesia management should be in constant attendance
• Adequate facilities for support of respiration and circulation should be available
• Administered with caution to patients with preexisting hypotension or in conditions where the hypnotic effect may be prolonged or intensified
• May be habit-forming
• Keep resuscitative and endotracheal intubation equipment and oxygen readily available
• Only persons qualified in the use of anesthetics should administer Thiopental
• Avoid extravasations or intra-arterial injection

Overdose Effects

• Too rapid or repeated administration may lead to overdosage
• Symptoms may include fall in blood pressure, apnoea, laryngospasm, coughing, and other respiratory difficulties

Therapeutic Class

• General (Intravenous) anesthetics

Storage Conditions

• Store at controlled room temperature of 15°C to 30°C
• Solutions should be freshly prepared and used immediately
• Any portion of the contents remaining should be discarded

Related Brands

• G-Thiopentone 500 mg/vial (IV Injection) - gonoshasthaya-pharma-ltd