Thioton 500 mg/vial (IV Injection)

Indications

• Sole anesthetic agent for brief procedures
• Induction of anesthesia prior to other anesthetic agents
• Supplement for regional anesthesia
• Provide hypnosis during balanced anesthesia
• Control of convulsive states
• Neurosurgical patients with increased intracranial pressure
• Narcoanalysis and narcosynthesis in psychiatric disorders

Composition

• Thiopental 500 mg injection
• Thiopental 1 gm injection
• Sterile mixture of Thiopental Sodium and anhydrous Sodium Carbonate
• Ampoule of 10 ml Water for Injection

Pharmacology

• Ultra-short-acting depressant of the central nervous system
• Induces hypnosis and anesthesia
• Binds at a distinct site associated with a Cl- ionopore at the GABA receptor
• Prolongs the post-synaptic inhibitory effect of GABA in the thalamus

Dosage & Administration

• Administered intravenously
• Normally as a 2.5% w/v solution
• Premedication with atropine or scopolamine
• Test dose of 25 mg to 75 mg to assess tolerance
• Normal dosage for induction of anesthesia
• Different dosages for adult, children, and elderly patients

Interaction

• Possible increase in difficulty in producing anesthesia with alcohol or CNS depressants
• Additive action with other CNS depressants
• Increased hypotension and excitatory effects with phenothiazine antipsychotics

Contraindications

• Absence of suitable veins for intravenous administration
• Hypersensitivity to barbiturates
• Variegate porphyria or acute intermittent porphyria
• Status asthmaticus
• Severe cardiovascular disease
• Hypotension or shock

Side Effects

• Respiratory depression
• Myocardial depression
• Cardiac arrhythmias
• Prolonged somnolence and recovery
• Hypotension
• Tachycardia
• Sneezing, coughing, bronchospasm
• Laryngospasm and shivering
• Anaphylactic reactions
• Urticaria, bronchospasm, vasodilation, and edema

Pregnancy & Lactation

• Pregnancy Category C
• Not known whether it can cause fetal harm
• Crosses the placental barrier
• May appear in the milk of nursing mothers

Precautions & Warnings

• Requires constant attendance and facilities for support
• Administered with caution in patients with preexisting hypotension
• May be habit-forming
• Resuscitative and endotracheal intubation equipment should be readily available

Overdose Effects

• Too rapid or repeated administration may lead to overdosage
• Alarming fall in blood pressure
• Apnoea, laryngospasm, and respiratory difficulties

Therapeutic Class

• General (Intravenous) anesthetics

Storage Conditions

• Store at controlled room temperature of 15°C to 30°C
• Solutions should be freshly prepared and used immediately
• Any remaining portion should be discarded

Related Brands

• Thiopen 500 mg/vial (IV Injection) - aci-limited
• G-Thiopentone 500 mg/vial (IV Injection) - gonoshasthaya-pharma-ltd