Acupain 30 mg/ml (IM/IV Injection)

1 ml ampoule: ৳ 60.00 (1 x 5: ৳ 300.00)

Medicine Details

Category Details
Generic Ketorolac tromethamine
Company Beacon pharmaceuticals plc
Also available as
Acupain 10 mg tablet

Indications

  • Short-term management of moderate to severe acute post-operative pain
  • Relieves pain, inflammation, and light sensitivity after ocular surgery
  • Decreases eye inflammation or redness caused by seasonal allergies

Description

  • Belongs to pyrrolo-pyrrole group of nonsteroidal anti-inflammatory drug (NSAID)
  • Chemical name: 5 benzoyle-2,3-dihydro-1H-pyrroligine-1-carboxylic acid, compound with 2 - amino-2-(hydroxymethyl)-1,3-propanediol (1:1)
  • Inhibits synthesis of prostaglandins
  • Metabolized in the liver

Pharmacology

  • Potent analgesic of the non-steroidal anti-inflammatory drugs (NSAIDs)
  • Inhibits the cyclooxygenase enzyme system and prostaglandin synthesis

Dosage & Administration

  • Tablet recommended dose: 10 mg every 4-6 hours
  • Injection used for moderately severe, acute pain on a regular or as-needed schedule
  • Maximum dose for adult IM dosing: 60 mg
  • Maximum dose for adult IV dosing: 30 mg
  • Eye Drops: Adults - 1 drop in each eye 4 times daily

Interaction

  • Other NSAIDs or aspirin: Increase the side effects of Acupain
  • Anti-coagulants: Enhance anti-coagulant effect
  • Beta Blocker: Reduce the anti-hypertensive effect
  • ACE Inhibitors: Increase the risk of renal impairment
  • Methotrexate: Enhance the toxicity of methotrexate

Contraindications

  • Hypersensitivity to the drug or other NSAIDs
  • Not for use in children under 16 years old
  • Contraindicated as a prophylactic analgesic before surgery

Side Effects

  • Nausea
  • Vomiting
  • Gastro-intestinal bleeding
  • Melena
  • Peptic ulcer
  • Pancreatitis
  • Anxiety
  • Drowsiness
  • Headache
  • Excessive thirst
  • Fatigue
  • Bradycardia
  • Hypertension
  • Palpitation
  • Chest pain
  • Infertility in females
  • Pulmonary edema

Pregnancy & Lactation

  • FDA Pregnancy category: C
  • Avoid in pregnancy and lactation unless benefits outweigh risks to the fetus

Precautions & Warnings

  • Exercise caution in patients over 65 years old
  • Caution in patients with active or suspected peptic ulcer, gastrointestinal bleeding, asthma, and liver dysfunction
  • Discontinue use of topical NSAIDs in patients with corneal epithelial breakdown
  • Do not use while wearing contact lenses

Therapeutic Class

  • Drugs used for Rheumatoid Arthritis
  • Non-Opioid Analgesics

Storage Conditions

  • Keep in a dry place away from light and heat
  • Keep out of the reach of children

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