Analac 30 mg/ml (IM/IV Injection)
1 ml ampoule: ৳ 55.00 (1 x 5: ৳ 275.00)
Medicine Details
| Category | Details |
|---|---|
| Generic | Ketorolac tromethamine |
| Company | Ziska pharmaceuticals ltd |
| Also available as |
Indications
- Short-term management of post-operative pain
- Relief of pain, inflammation, and light sensitivity after ocular surgery
- Reduction of eye inflammation or redness caused by seasonal allergies
Description
- Belongs to the pyrrolo-pyrrole group of nonsteroidal anti-inflammatory drugs
- Chemical name: 5 benzoyle-2,3-dihydro-1H-pyrroligine-1-carboxylic acid, compound with 2 - amino-2-(hydroxymethyl)-1,3-propanediol (1:1)
- Inhibits synthesis of prostaglandins
- Biological activity associated with S-form
- Linear pharmacokinetic property
- Highly protein bound
- Metabolized in the liver
- Excretion in the urine
Pharmacology
- Potent analgesic of NSAIDs
- Inhibits cyclooxygenase enzyme system
- Minimal anti-inflammatory effect at analgesic dose
Dosage & Administration
- Tablet recommended dose: 10 mg every 4-6 hours for short-term use
- Injection for management of moderately severe, acute pain
- Different dosing for patients of various age groups and conditions
- IM and IV administration guidelines
- Duration of analgesic effect
Interaction
- Increase in side effects with other NSAIDs or aspirin
- Enhanced anti-coagulant effect with anti-coagulants
- Reduction in anti-hypertensive effect with Beta Blockers
- Increased risk of renal impairment with ACE Inhibitors
- Enhanced toxicity of methotrexate
Contraindications
- Hypersensitivity to Ketorolac or other NSAIDs
- Children under 16 years old
- Prophylactic analgesic before surgery
Side Effects
- Nausea
- Vomiting
- GI bleeding
- Peptic ulcer
- Pancreatitis
- Anxiety
- Drowsiness
- Headache
- Excessive thirst
- Fatigue
- Bradycardia
- Hypertension
- Palpitation
- Chest pain
- Infertility in females
- Pulmonary edema
Pregnancy & Lactation
- US FDA Pregnancy category: C
- Avoid in pregnancy and lactation unless benefits outweigh risks
Precautions & Warnings
- Caution in patients over 65 years old
- Caution in patients with peptic ulcer, gastrointestinal bleeding, asthma, and liver dysfunction
- Immediate discontinuation in case of corneal epithelial breakdown for topical NSAIDs
- Avoid administration while wearing contact lenses
Therapeutic Class
- Drugs used for Rheumatoid Arthritis
- Non-Opioid Analgesics
Storage Conditions
- Dry place away from light and heat
- Keep out of the reach of children