Arolak 30 mg/ml (IM/IV Injection)

1 ml ampoule: ৳ 55.20 (5's pack: ৳ 276.00)

Medicine Details

Category Details
Generic Ketorolac tromethamine
Company Ambee pharmaceuticals ltd
Also available as
Arolak 10 mg tablet Arolak 10 mg injection

Indications

  • Short-term management of post-operative pain
  • Relief of pain and inflammation after ocular surgery
  • Decrease in eye inflammation or redness due to allergies

Description

  • Arolak is a nonsteroidal anti-inflammatory drug (NSAID)
  • Chemical name: 5 benzoyle-2,3-dihydro-1H-pyrroligine-1-carboxylic acid, compound with 2 - amino-2-(hydroxymethyl)-1,3-propanediol
  • Inhibits synthesis of prostaglandins
  • Biological activity associated with the S-form
  • Linear pharmacokinetic property
  • Highly protein bound
  • Metabolized in the liver
  • Metabolites and unchanged drug excreted in urine

Pharmacology

  • Potent analgesic
  • Inhibits cyclooxygenase enzyme system
  • Minimal anti-inflammatory effect at analgesic dose

Dosage & Administration

  • Tablet: Recommended dose is 10 mg every 4-6 hours for short-term use
  • Injection: Used for management of moderately severe, acute pain, with specific dosing based on age, weight, and route of administration
  • Eye Drops: Adult dosage is 1 drop in each eye 4 times daily

Interaction

  • Other NSAIDs or aspirin increase side effects
  • Anti-coagulants enhance anti-coagulant effect
  • Beta Blockers reduce anti-hypertensive effect
  • ACE Inhibitors increase risk of renal impairment
  • Methotrexate enhances toxicity of methotrexate

Contraindications

  • Hypersensitivity to ketorolac or other NSAIDs
  • Children under 16 years of age
  • Prophylactic analgesic before surgery

Side Effects

  • Nausea
  • Vomiting
  • Gastro-intestinal bleeding
  • Melena
  • Peptic ulcer
  • Pancreatitis
  • Anxiety
  • Drowsiness
  • Headache
  • Excessive thirst
  • Fatigue
  • Bradycardia
  • Hypertension
  • Palpitation
  • Chest pain
  • Infertility in females
  • Pulmonary edema

Pregnancy & Lactation

  • Pregnancy category C - avoid unless benefits outweigh risks

Precautions & Warnings

  • Caution in patients over 65 years
  • Caution in patients with peptic ulcer, gastrointestinal bleeding, asthma, and liver dysfunction
  • Discontinue use of topical NSAIDs with corneal epithelial breakdown
  • Avoid use while wearing contact lenses

Therapeutic Class

  • Drugs used for Rheumatoid Arthritis
  • Non-Opioid Analgesics

Storage Conditions

  • Keep in a dry place away from light and heat
  • Keep out of the reach of children

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