Kenodol 10 mg (Tablet)

Unit Price: ৳ 12.03 (3 x 10: ৳ 360.90)
Strip Price: ৳ 120.30

Medicine Details

Category Details
Generic Ketorolac tromethamine
Company Rangs pharmaceuticals ltd
Also available as
Kenodol 30 mg injection Kenodol 60 mg injection

Indications

  • Short-term management of moderate to severe acute post-operative pain
  • Relieves pain, inflammation, and light sensitivity after ocular surgery
  • Decreases eye inflammation or redness caused by seasonal allergies

Description

  • Belongs to the pyrrolo-pyrrole group of nonsteroidal anti-inflammatory drug (NSAID)
  • Chemical name: 5 benzoyle-2,3-dihydro-1H-pyrroligine-1-carboxylic acid, compound with 2 - amino-2-(hydroxymethyl)-1,3-propanediol (1:1)
  • Inhibits synthesis of prostaglandins
  • Peripherally acting analgesic
  • Biological activity associated with the S-form
  • Linear pharmacokinetic property
  • Highly protein bound
  • Largely metabolized in the liver
  • Metabolites and some unchanged drugs excreted in the urine

Pharmacology

  • Potent analgesic of the non-steroidal anti-inflammatory drugs (NSAIDs)
  • Inhibits the cyclooxygenase enzyme system
  • Minimal anti-inflammatory effect at analgesic dose

Dosage & Administration

  • Tablet: Recommended dose is 10 mg every 4-6 hours for up to 7 days
  • Injection: Doses should not exceed 40 mg/day. IV bolus must be given over no less than 15 seconds.
  • IM administration should be given slowly and deeply into the muscle
  • Analgesic effect begins within 30 minutes with maximum effect in 1 to 2 hours after dosing IV or IM
  • Duration of analgesic effect is usually 4 to 6 hours
  • Eye Drops: Adults should use 1 drop in each eye 4 times daily

Interaction

  • Other NSAIDs or aspirin increases the side effects
  • Anti-coagulants enhance anti-coagulant effect
  • Beta Blocker reduces the anti-hypertensive effect
  • ACE Inhibitors increase the risk of renal impairment
  • Methotrexate enhances the toxicity of methotrexate

Contraindications

  • Hypersensitivity to this drug or other NSAIDs
  • Use in children under 16 years of age
  • Prophylactic analgesic before surgery

Side Effects

  • Nausea
  • Vomiting
  • Gastro-intestinal bleeding
  • Melena
  • Peptic ulcer
  • Pancreatitis
  • Anxiety
  • Drowsiness
  • Headache
  • Excessive thirst
  • Fatigue
  • Bradycardia
  • Hypertension
  • Palpitation
  • Chest pain
  • Infertility in females
  • Pulmonary edema

Pregnancy & Lactation

  • US FDA Pregnancy category of Ketorolac Tromethamine is C
  • Avoid in pregnancy and lactation unless benefits outweigh possible risks

Precautions & Warnings

  • Caution in patients over the age of 65 years
  • Caution in patients with active or suspected peptic ulcer or gastrointestinal bleeding, asthma, and liver dysfunction
  • Patients with evidence of corneal epithelial breakdown should discontinue use of topical NSAIDs and should be closely monitored for corneal health

Therapeutic Class

  • Rheumatoid Arthritis
  • Non-Opioid Analgesics

Storage Conditions

  • Keep in a dry place away from light and heat
  • Keep out of the reach of children

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