Kepros 30 mg/ml (IM/IV Injection)
1 ml ampoule: ৳ 55.00 (1 x 5: ৳ 275.00)
Medicine Details
| Category | Details |
|---|---|
| Generic | Ketorolac tromethamine |
| Company | Monicopharma ltd |
| Also available as |
Indications
- Short-term management of post-operative pain
- Relief from pain, inflammation, and light sensitivity after ocular surgery
- Decrease eye inflammation or redness caused by seasonal allergies
Description
- Belongs to the pyrrolo-pyrrole group of nonsteroidal anti-inflammatory drug (NSAID)
- Chemical composition: 5 benzoyle-2,3-dihydro-1H-pyrroligine-1-carboxylic acid, compound with 2 - amino-2-(hydroxymethyl)-1,3-propanediol (1:1)
- Inhibits synthesis of prostaglandins
- Biological activity associated with the S-form
- Linear pharmacokinetic property
- Highly protein bound
- Metabolized in the liver
- Products of metabolism and some unchanged drugs are excreted in the urine
Pharmacology
- Potent analgesic of the non-steroidal anti-inflammatory drugs (NSAIDs)
- Inhibits the cyclooxygenase enzyme system
- Demonstrates minimal anti-inflammatory effect at analgesic dose
Dosage & Administration
- Tablet: Recommended dose is 10 mg every 4-6 hours for short-term use only
- Injection: Single or multiple doses for postoperative pain management
- Onset of analgesic effect within 30 minutes
- Maximum effect in 1 to 2 hours after dosing
- Duration of analgesic effect is usually 4 to 6 hours
- Dosage varies for different age groups and conditions
- Eye Drops: Adults - 1 drop in each eye 4 times daily
Interaction
- Other NSAIDs or aspirin: Increase the side effects
- Anti-coagulants: Enhance anti-coagulant effect
- Beta Blocker: Reduce the anti-hypertensive effect
- ACE Inhibitors: Increase the risk of renal impairment
- Methotrexate: Enhance the toxicity
Contraindications
- Hypersensitivity to the drug or other NSAIDs
- Not recommended for use in children under 16 years of age
- Contraindicated as prophylactic analgesic before surgery
Side Effects
- Nausea
- Vomiting
- Gastro-intestinal bleeding
- Melena
- Peptic ulcer
- Pancreatitis
- Anxiety
- Drowsiness
- Headache
- Excessive thirst
- Fatigue
- Bradycardia
- Hypertension
- Palpitation
- Chest pain
- Infertility in females
- Pulmonary edema
Pregnancy & Lactation
- Pregnancy category of Ketorolac Tromethamine is C
- Avoid use in pregnancy and lactation unless benefits outweigh risks
Precautions & Warnings
- Caution in patients over the age of 65
- Caution in patients with active or suspected peptic ulcer or gastrointestinal bleeding
- Caution in patients with asthma and liver dysfunction
- Discontinue use of topical NSAIDs in patients with evidence of corneal epithelial breakdown
- Do not administer while wearing contact lenses
Therapeutic Class
- Rheumatoid Arthritis Drugs
- Non-Opioid Analgesics
Storage Conditions
- Keep in a dry place away from light and heat
- Keep out of the reach of children