Ketonic 30 mg/ml (IM/IV Injection)

1 ml ampoule: ৳ 55.00

Medicine Details

Category Details
Generic Ketorolac tromethamine
Company Eskayef pharmaceuticals ltd
Also available as
Ketonic 10 mg tablet Ketonic 60 mg injection

Indications

  • Management of acute post-operative pain
  • Relief of pain after ocular surgery
  • Reduction of eye inflammation caused by allergies

Description

  • Belongs to pyrrolo-pyrrole group of nonsteroidal anti-inflammatory drug (NSAID)
  • Chemical name: 5 benzoyle-2,3-dihydro-1H-pyrroligine-1-carboxylic acid, compound with 2-amino-2-(hydroxymethyl)-1,3-propanediol
  • Inhibits synthesis of prostaglandins
  • Biological activity associated with the S-form
  • Highly protein bound
  • Metabolized in the liver
  • Metabolites and some unchanged drug excreted in urine

Pharmacology

  • Potent analgesic
  • Acts by inhibiting cyclooxygenase enzyme system
  • Minimal anti-inflammatory effect at analgesic dose

Dosage & Administration

  • Tablet: recommended dose is 10 mg every 4-6 hours for short-term use
  • Injection: may be used for moderately severe, acute pain management
  • Injection: IV bolus must be given over no less than 15 seconds
  • Injection for adult IM dosing: one dose of 60 mg for <65 years, 30 mg for >65 years or renally impaired and/or <50 kg
  • Injection for adult IV dosing: one dose of 30 mg for <65 years, 15 mg for >65 years or renally impaired and/or <50 kg
  • Injection for 2 to 16 years old: IM dosing one dose of 1 mg/kg up to a maximum of 30 mg, IV dosing one dose of 0.5 mg/kg up to a maximum of 15 mg
  • Eye Drops: Adults: 1 drop in each eye 4 times daily

Interaction

  • Other NSAIDs or aspirin increase the side effects of Ketonic
  • Anti-coagulants enhance anti-coagulant effect
  • Beta Blocker reduce the anti-hypertensive effect
  • ACE Inhibitors increase the risk of renal impairment
  • Methotrexate enhance the toxicity of methotrexate

Contraindications

  • Hypersensitivity to the drug or other NSAIDs
  • Use in children under 16 years of age
  • Prophylactic analgesic before surgery

Side Effects

  • Nausea
  • Vomiting
  • Gastro-intestinal bleeding
  • Melena
  • Peptic ulcer
  • Pancreatitis
  • Anxiety
  • Drowsiness
  • Headache
  • Excessive thirst
  • Fatigue
  • Bradycardia
  • Hypertension
  • Palpitation
  • Chest pain
  • Infertility in female
  • Pulmonary edema

Pregnancy & Lactation

  • US FDA Pregnancy category: C
  • Avoid in pregnancy and lactation unless benefits outweigh risks

Precautions & Warnings

  • Caution in patients over 65 years
  • Caution in patients with active peptic ulcer or gastrointestinal bleeding
  • Caution in patients with asthma and liver dysfunction
  • Eye Drops: avoid in patients with corneal epithelial breakdown
  • Eye Drops: avoid use with contact lenses

Therapeutic Class

  • Rheumatoid Arthritis medication
  • Non-Opioid Analgesic

Storage Conditions

  • Keep in a dry place away from light and heat
  • Keep out of the reach of children

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