Ketorin 30 mg/ml (IM/IV Injection)
1 ml ampoule: ৳ 55.16
Medicine Details
| Category | Details |
|---|---|
| Generic | Ketorolac tromethamine |
| Company | Orion pharma ltd |
| Also available as |
Title
- Ketorin
- Ketorolac Tromethamine
Categories
- Nonsteroidal Anti-Inflammatory Drug (NSAID)
- Pain Management
- Ophthalmic Solution
- Analgesic
- Eye Drops
- Tablet
- Injection
Indications
- Management of moderate to severe acute post-operative pain
- Relief of pain, inflammation, and light sensitivity after ocular surgery
- Decrease eye inflammation or redness caused by seasonal allergies
Description
- Belongs to the pyrrolo-pyrrole group of NSAIDs
- Chemical composition: 5 benzoyle-2,3-dihydro-1H-pyrroligine-1-carboxylic acid, compound with 2-amino-2-(hydroxymethyl)-1,3-propanediol (1:1)
- Inhibits synthesis of prostaglandins
- Biologically active form is the S-form
- Pharmacokinetic property is linear
- Highly protein bound
- Largely metabolized in the liver
- Excretion in the urine
Pharmacology
- Acts by inhibiting the cyclooxygenase enzyme system
- Minimal anti-inflammatory effect at its analgesic dose
Dosage & Administration
- Tablet recommended dose: 10 mg every 4-6 hours for up to 7 days
- Injection for postoperative pain management
- Onset of analgesic effect within 30 minutes
- Maximum effect in 1 to 2 hours after dosing IV or IM
- Duration of analgesic effect: 4 to 6 hours
- Specific dosages for different age groups and conditions
Interactions
- Increased side effects with other NSAIDs or aspirin
- Enhanced anti-coagulant effect with anti-coagulants
- Reduced anti-hypertensive effect with Beta Blockers
- Increased risk of renal impairment with ACE Inhibitors
- Enhanced toxicity of methotrexate
Contraindications
- Hypersensitivity to Ketorolac or other NSAIDs
- Not for use in children under 16 years of age
- Contraindicated as prophylactic analgesic before surgery
Side Effects
- Nausea
- Vomiting
- Gastro-intestinal bleeding
- Melena
- Peptic ulcer
- Pancreatitis
- Anxiety
- Drowsiness
- Headache
- Excessive thirst
- Fatigue
- Bradycardia
- Hypertension
- Palpitation
- Chest pain
- Infertility in females
- Pulmonary edema
Pregnancy & Lactation
- US FDA Pregnancy category: C
- Avoided in pregnancy and lactation unless benefits outweigh risks
Precautions & Warnings
- Caution in patients over 65 years
- Caution in patients with active or suspected peptic ulcer, gastrointestinal bleeding, asthma, or liver dysfunction
- Immediate discontinuation in case of corneal epithelial breakdown
- Avoid use while wearing contact lenses (for ophthalmic solution)
Therapeutic Class
- Rheumatoid Arthritis
- Non-Opioid Analgesics
Storage Conditions
- Keep in a dry place away from light and heat
- Keep out of the reach of children