Lixidol 10 mg (Tablet)

Unit Price: ৳ 10.00 (30's pack: ৳ 300.00)

Medicine Details

Category Details
Generic Ketorolac tromethamine
Company Cosmic pharma ltd

Indications

  • Short-term management of moderate to severe acute post-operative pain
  • Relieves pain, inflammation, and light sensitivity after ocular surgery
  • Decreases eye inflammation or redness caused by seasonal allergies

Description

  • Belongs to the pyrrolo-pyrrole group of nonsteroidal anti-inflammatory drugs (NSAID)
  • Chemical name: 5 benzoyle-2,3-dihydro-1H-pyrroligine-1-carboxylic acid, compound with 2-amino-2-(hydroxymethyl)-1,3-propanediol (1:1)
  • Inhibits synthesis of prostaglandins
  • Peripherally acting analgesic
  • Biological activity associated with the S-form
  • Pharmacokinetic property is linear
  • Highly protein bound
  • Metabolized in the liver
  • Metabolites and some unchanged drugs are excreted in the urine

Pharmacology

  • Potent analgesic within the non-steroidal anti-inflammatory drugs (NSAIDs) class
  • Inhibits the cyclooxygenase enzyme system
  • Minimal anti-inflammatory effect at analgesic dose

Dosage & Administration

  • Recommended tablet dose: 10mg every 4-6 hours for short-term use (up to 7 days)
  • Tablet doses exceeding 40mg/day not recommended
  • Injection for management of moderately severe acute pain, single or multiple doses
  • IV bolus administration over at least 15 seconds
  • IM administration should be given slowly and deeply into the muscle
  • Analgesic effect begins within 30 minutes with maximum effect in 1 to 2 hours after dosing IV or IM
  • Duration of analgesic effect is usually 4 to 6 hours
  • Specific dosing guidelines for different age groups and conditions
  • 30mg Ketorolac injection every 6 hours for patients under 65 years of age
  • 15mg Ketorolac injection every 6 hours for elderly and renally impaired patients
  • Additional guidance for conversion from parenteral to oral therapy
  • Specific dosing guidance for eye drops

Interaction

  • Increased side effects with other NSAIDs or aspirin
  • Enhanced anti-coagulant effect with anti-coagulants
  • Reduced anti-hypertensive effect with beta blockers
  • Increased risk of renal impairment with ACE Inhibitors
  • Enhanced toxicity of methotrexate

Contraindications

  • Hypersensitivity to Ketorolac or other NSAIDs
  • Not to be used in children under 16 years of age
  • Contraindicated as prophylactic analgesic before surgery

Side Effects

  • Nausea
  • Vomiting
  • Gastrointestinal bleeding
  • Melena
  • Peptic ulcer
  • Pancreatitis
  • Anxiety
  • Drowsiness
  • Headache
  • Excessive thirst
  • Fatigue
  • Bradycardia
  • Hypertension
  • Palpitation
  • Chest pain
  • Infertility in females
  • Pulmonary edema

Pregnancy & Lactation

  • US FDA Pregnancy category: C
  • Avoid in pregnancy and lactation unless potential benefits outweigh possible risks to the fetus

Precautions & Warnings

  • Exercise caution in patients over the age of 65 years
  • Caution in patients with active or suspected peptic ulcer, gastrointestinal bleeding, asthma, and liver dysfunction
  • Additional precautions for eye drop usage, including corneal health monitoring

Therapeutic Class

  • Rheumatoid Arthritis
  • Non-Opioid Analgesics

Storage Conditions

  • Keep in a dry place away from light and heat
  • Keep out of the reach of children

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