Domilin 10 mg (Tablet)

Unit Price: ৳ 4.00 (10 x 10: ৳ 400.00)
Strip Price: ৳ 40.00

Medicine Details

Category Details
Generic Domperidone maleate
Company General pharmaceuticals ltd
Also available as
Domilin 5 mg suspension

Title

  • Domilin 10 mg Tablet

Categories

  • Medicine
  • Pharmaceuticals
  • Healthcare

Description

  • A medication to treat dyspeptic symptom complex
  • Used for acute nausea and vomiting
  • May be beneficial for Parkinson's disease
  • Aids in speeding barium transit in radiological studies
  • Restores normal motility and tone of the upper gastrointestinal tract
  • Facilitates gastric emptying

Dosage & Administration

  • Should be taken 15-30 minutes before meals
  • Usual recommended oral dose for adults is 10-20 mg every 6-8 hours daily
  • Usual recommended oral dose for children is 2-4 ml suspension/10 kg body weight or 0.4-0.8 ml paediatric drops/10 kg body weight, every 6-8 hours daily
  • Rectal administration for adults: 30-60 mg every 4-8 hours

Pharmacology

  • Dopamine antagonist
  • Blocks dopamine receptors in the Chemoreceptor Trigger Zone (CTZ) and stomach
  • Restores normal motility and tone of the upper gastrointestinal tract
  • Facilitates gastric emptying
  • Enhances antral and duodenal peristalsis

Interaction

  • Concomitant administration of anticholinergic drugs may antagonize the antidyspeptic effect of domperidone
  • Antacids and antisecretory drugs should not be given simultaneously with domperidone as they lower its oral bioavailability
  • In vitro data suggest that the concomitant use of drugs that significantly inhibit the CYP3A4 enzyme may result in increased plasma levels of domperidone

Contraindications

  • Known hypersensitivity to the drug
  • Neonates
  • Gastrointestinal hemorrhage
  • Mechanical obstruction or perforation
  • Prolactin releasing pituitary tumor (prolactinoma)

Side Effects

  • Transient intestinal cramps
  • Extrapyramidal phenomena
  • Increase in plasma prolactin level
  • Rare allergic reactions such as rash and urticaria

Pregnancy & Lactation

  • Should only be used during the first trimester of pregnancy if justified by the anticipated therapeutic benefit
  • No evidence of increase in the risk of malformations in humans
  • Not known whether excretion in breast milk is harmful to the newborn

Precautions & Warnings

  • Use with caution in children due to increased risk of extrapyramidal reactions
  • Use with caution in patients with hepatic impairment

Use in Special Populations

  • Use in infants should be with great caution and under close medical supervision
  • Use with caution in liver and kidney disorders

Overdose Effects

  • Symptoms may include drowsiness, disorientation, and extrapyramidal reactions
  • Recommendation for administration of activated charcoal and close patient observation

Therapeutic Class

  • Motility Stimulants
  • Dopamine antagonist
  • Prokinetic drugs

Storage Conditions

  • Store below 30°C
  • Protected from light and moisture
  • Keep out of children's reach

Chemical Structure

  • Molecular Formula: C22H24ClN5O2

Common Questions

  • Used to treat nausea and vomiting
  • Helps relieve nausea, vomiting, and indigestion
  • May cause dizziness and sleepiness
  • Avoid consuming alcohol when taking the medication

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