Oradol 30 mg/ml (IM/IV Injection)

1 ml ampoule: ৳ 55.00

Medicine Details

Category Details
Generic Ketorolac tromethamine
Company Aristopharma ltd
Also available as
Oradol 10 mg tablet Oradol 60 mg injection

Title

Oradol Medicine

Categories

  • Pain Management
  • Ophthalmic Solutions
  • NSAIDs
  • Analgesics
  • Therapeutic Drugs

Description

  • Effective for short-term management of moderate to severe acute post-operative pain
  • Inhibits prostaglandin synthesis
  • Potent analgesic and anti-inflammatory effect
  • Metabolized in the liver
  • Highly protein bound
  • Linear pharmacokinetic property

Indications

  • Short-term management of moderate to severe acute post-operative pain
  • Relief of pain, inflammation, and light sensitivity after ocular surgery
  • Decrease eye inflammation or redness caused by seasonal allergies

Pharmacology

  • Potent analgesic of the non-steroidal anti-inflammatory drugs (NSAIDs)
  • Inhibits the cyclooxygenase enzyme system
  • Minimal anti-inflammatory effect at analgesic dose

Dosage and administration

  • Recommended dosage of 10 mg every 4-6 hours (tablet)
  • Single or multiple doses for postoperative pain management (injection)
  • Specific dosages for different age groups and conditions
  • Eye drops: 1 drop in each eye 4 times daily

Interaction

  • Increase in side effects with other NSAIDs or aspirin
  • Enhanced anti-coagulant effect with anti-coagulants
  • Reduced anti-hypertensive effect with beta blockers
  • Increased risk of renal impairment with ACE inhibitors
  • Enhanced toxicity of methotrexate

Contraindications

  • Hypersensitivity to Ketorolac or other NSAIDs
  • Children under 16 years of age
  • Prophylactic analgesic before surgery

Side effects

  • Nausea
  • Vomiting
  • Gastro-intestinal bleeding
  • Melena
  • Peptic ulcer
  • Pancreatitis
  • Anxiety
  • Drowsiness
  • Headache
  • Excessive thirst
  • Fatigue
  • Bradycardia
  • Hypertension
  • Palpitation
  • Chest pain
  • Infertility in females
  • Pulmonary edema

Pregnancy and lactation

  • FDA Pregnancy category C
  • Avoid in pregnancy and lactation unless benefits outweigh risks to the fetus

Precautions and warnings

  • Caution in patients over 65 years
  • Caution in patients with peptic ulcer, gastrointestinal bleeding, asthma, and liver dysfunction
  • Discontinue use in case of corneal epithelial breakdown (eye drops)
  • Avoid use with contact lenses (eye drops)

Therapeutic class

  • Rheumatoid Arthritis Drugs
  • Non-Opioid Analgesics

Storage conditions

  • Store in a dry place away from light and heat
  • Keep out of the reach of children

Chemical composition

  • Pyrrolo-pyrrole group of NSAIDs
  • Chemical name: 5-benzoyle-2,3-dihydro-1H-pyrroligine-1-carboxylic acid, compound with 2-amino-2-(hydroxymethyl)-1,3-propanediol (1:1)
  • Biological activity associated with the S-form
  • Metabolized and excreted in the urine

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