Pair 30 mg/ml (IM/IV Injection)

1 ml ampoule: ৳ 55.20

Medicine Details

Category Details
Generic Ketorolac tromethamine
Company Drug international ltd
Also available as
Pair 10 mg tablet Pair 05 eye drop

Indications

  • Short-term management of moderate to severe acute post-operative pain
  • Relieves pain, inflammation, and light sensitivity after ocular surgery
  • Decreases eye inflammation or redness caused by seasonal allergies

Description

  • Belongs to pyrrolo-pyrrole group of nonsteroidal anti-inflammatory drug (NSAID)
  • Chemical composition: 5 benzoyle-2,3-dihydro-1H-pyrroligine-1-carboxylic acid, compound with 2 - amino-2-(hydroxymethyl)-1,3-propanediol (1:1)
  • Inhibits synthesis of prostaglandins
  • Biological activity associated with the S-form
  • Linear pharmacokinetic property
  • Highly protein bound
  • Metabolized in the liver
  • Products of metabolism and some unchanged drugs are excreted in the urine

Pharmacology

  • Potent analgesic NSAID
  • Inhibits the cyclooxygenase enzyme system
  • Demonstrates minimal anti-inflammatory effect at its analgesic dose

Dosage & Administration

  • Tablet recommended dose: 10 mg every 4-6 hours for short-term use (up to 7 days)
  • Injection used for postoperative pain management and analgesia at the opioid level
  • IV bolus administration over at least 15 seconds
  • IM administration given slowly and deeply into the muscle
  • Onset of analgesic effect within 30 minutes with maximum effect in 1 to 2 hours after dosing IV or IM
  • Duration of analgesic effect is usually 4 to 6 hours
  • Various dosing recommendations based on age, weight, and renal function

Interaction

  • Increased side effects with other NSAIDs or aspirin
  • Enhanced anti-coagulant effect with anti-coagulants
  • Reduced anti-hypertensive effect with beta blockers
  • Increased risk of renal impairment with ACE inhibitors
  • Enhanced toxicity of methotrexate

Contraindications

  • Hypersensitivity to ketorolac or other NSAIDs
  • Not for use in children under 16 years of age
  • Contraindicated as prophylactic analgesic before surgery

Side Effects

  • Nausea
  • Vomiting
  • Gastro-intestinal bleeding
  • Melena
  • Peptic ulcer
  • Pancreatitis
  • Anxiety
  • Drowsiness
  • Headache
  • Excessive thirst
  • Fatigue
  • Bradycardia
  • Hypertension
  • Palpitation
  • Chest pain
  • Infertility in females
  • Pulmonary edema

Pregnancy & Lactation

  • US FDA Pregnancy category: C
  • Ketorolac should be avoided in pregnancy and lactation unless benefits outweigh risks to the fetus

Precautions & Warnings

  • Caution in patients over the age of 65 years
  • Caution in patients with active or suspected peptic ulcer, gastrointestinal bleeding, asthma, and liver dysfunction
  • Discontinue use and closely monitor corneal health if evidence of corneal epithelial breakdown
  • Avoid administration while wearing contact lenses

Therapeutic Class

  • Non-Opioid Analgesics

Storage Conditions

  • Keep in a dry place away from light and heat
  • Keep out of the reach of children

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