Domilin 5 mg/5 ml (Oral Suspension)

100 ml bottle: ৳ 40.27

Medicine Details

Category Details
Generic Domperidone maleate
Company General pharmaceuticals ltd
Also available as
Domilin 10 mg tablet

Title

  • Domilin 5 mg/5 ml Suspension

Categories

  • Medicine
  • Gastrointestinal
  • Pharmacology
  • Therapeutic Class: Motility Stimulants/Dopamine antagonist

Description

  • Dopamine antagonist medication
  • Relieves nausea and vomiting
  • Blocks dopamine receptors in Chemoreceptor Trigger Zone and stomach
  • Restores normal motility and tone of the upper gastrointestinal tract
  • Facilitates gastric emptying
  • Enhances antral and duodenal peristalsis
  • Regulates contraction of the pylorus
  • Increases esophageal peristalsis
  • Lowers esophageal sphincter pressure
  • Prevents regurgitation of gastric content
  • Recommended to be taken 15-30 minutes before meals
  • Usual recommended oral dose: 10-20 mg for adults, 2-4 ml suspension/10 kg body weight for children
  • Contraindicated in patients with known hypersensitivity or gastrointestinal hemorrhage, mechanical obstruction, perforation
  • Should be used with caution in children and patients with hepatic impairment or severe renal insufficiency

Color Options

  • Not applicable

Dimensions

  • Not applicable

Functions

  • Relieves dyspeptic symptom complex
  • Treats acute nausea and vomiting
  • Speeds barium transit in radiological studies

Materials

  • Not applicable

Technical Specifications

  • Molecular Formula: C22H24ClN5O2
  • Maximum dose: 80 mg daily
  • Dosing frequency may need to be reduced in patients with severe renal insufficiency
  • Store below 30°C, protected from light & moisture

Design Elements

  • Suspension form
  • Dosage in ml and tablet form
  • Paediatric drops available

Usability Features

  • Patients should be reviewed regularly if on prolonged therapy
  • Effects on ability to drive and use machines: Does not affect mental alertness
  • Contraindicated in neonates
  • Not recommended for nursing mothers

Interaction

  • Antagonized by anticholinergic drugs
  • Lower bioavailability when given with antacids and antisecretory drugs
  • Metabolic pathway through CYP3A4
  • Inhibition of this enzyme may increase plasma levels of domperidone
  • Potential influence on absorption of concomitantly orally administered drugs

Dosage & Administration

  • 10-20 mg (1-2 tablet or 10-20 ml suspension) every 6-8 hours for adults
  • 2-4 ml suspension/10 kg body weight or 0.4-0.8 ml paediatric drops/10 kg body weight every 6-8 hours for children
  • Rectal administration in adults and children
  • Maximum treatment period for acute nausea and vomiting is 12 weeks

Indications

  • Dyspeptic symptom complex
  • Acute nausea and vomiting
  • Functional, organic, infectious, dietetic origin nausea and vomiting
  • Dopamine-agonist induced nausea and vomiting in Parkinson's disease
  • Speeding barium transit in follow-through radiological studies

Contraindications

  • Known hypersensitivity
  • Neonates
  • Gastrointestinal stimulation might be dangerous
  • Patients with prolactin releasing pituitary tumor

Side Effects

  • Transient intestinal cramps
  • Extrapyramidal phenomena
  • Increase in plasma prolactin level
  • Rare allergic reactions such as rash and urticaria

Pregnancy & Lactation

  • Should only be used during the first trimester if justified by therapeutic benefit
  • No evidence of increase in risk of malformations in humans
  • Not recommended for nursing mothers unless expected benefits outweigh potential risk
  • Does not affect mental alertness

Precautions & Warnings

  • Increased risk of extra-pyramidal reactions in young children
  • Highly metabolized in liver, caution in patients with hepatic impairment

Use in Special Populations

  • Use with caution in infants and under close medical supervision
  • Caution in patients with hepatic impairment or severe renal insufficiency

Overdose Effects

  • Drowsiness
  • Disorientation
  • Extrapyramidal reactions
  • Activated charcoal recommended for overdosage

Therapeutic Class

  • Motility Stimulants
  • Dopamine antagonist
  • Prokinetic drugs

Storage Conditions

  • Store below 30°C, protected from light & moisture
  • Keep out of children's reach

Chemical Structure

  • Molecular Formula: C22H24ClN5O2

Commonly Asked Questions

  • Used to treat nausea and vomiting
  • Quick tips for usage and precautions

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