Perilac 30 mg/ml (IM/IV Injection)

1 ml ampoule: ৳ 60.00 (1 x 5: ৳ 300.00)

Medicine Details

Category Details
Generic Ketorolac tromethamine
Company Biopharma limited
Also available as
Perilac 10 mg tablet Perilac 60 mg injection

Indications

  • Short-term management of moderate to severe acute post-operative pain
  • Relief of pain, inflammation, and light sensitivity after ocular surgery
  • Decrease in eye inflammation or redness caused by seasonal allergies

Description

  • Belongs to pyrrolo-pyrrole group of nonsteroidal anti-inflammatory drugs (NSAID)
  • Chemical composition: 5 benzoyle-2,3-dihydro-1H-pyrroligine-1-carboxylic acid, compound with 2 - amino-2-(hydroxymethyl)-1,3-propanediol (1:1)
  • Inhibits synthesis of prostaglandins
  • Biological activity associated with the S-form
  • Pharmacokinetic properties: linear, highly protein bound, largely metabolized in the liver

Pharmacology

  • Acts by inhibiting the cyclooxygenase enzyme system
  • Minimal anti-inflammatory effect at analgesic dose

Dosage & Administration

  • Tablet recommended dose: 10 mg every 4-6 hours for short-term use (up to 7 days)
  • Injection recommended for the management of moderately severe, acute pain
  • IM administration should be given slowly and deeply into the muscle
  • Duration of analgesic effect is usually 4 to 6 hours
  • Eye Drops: Adults - 1 drop in each eye 4 times daily

Interaction

  • Increased side effects with other NSAIDs or aspirin
  • Enhanced anti-coagulant effect with anti-coagulants
  • Reduced anti-hypertensive effect with Beta Blockers
  • Increased risk of renal impairment with ACE Inhibitors
  • Enhanced toxicity of methotrexate

Contraindications

  • Hypersensitivity to Ketorolac or other NSAIDs
  • Children under 16 years of age
  • Prophylactic analgesic use before surgery

Side Effects

  • Nausea
  • Vomiting
  • Gastro-intestinal bleeding
  • Melena
  • Peptic ulcer
  • Pancreatitis
  • Anxiety
  • Drowsiness
  • Headache
  • Excessive thirst
  • Fatigue
  • Bradycardia
  • Hypertension
  • Palpitation
  • Chest pain
  • Infertility in females
  • Pulmonary edema

Pregnancy & Lactation

  • US FDA Pregnancy category - C
  • Avoid use in pregnancy and lactation unless potential benefits outweigh risks to the fetus

Precautions & Warnings

  • Caution in patients over age 65
  • Caution in patients with active or suspected peptic ulcer or gastrointestinal bleeding, asthma, and liver dysfunction
  • For Eye Drops: Discontinue use in case of corneal epithelial breakdown

Therapeutic Class

  • Drugs used for Rheumatoid Arthritis
  • Non-Opioid Analgesics

Storage Conditions

  • Keep in a dry place away from light and heat
  • Keep out of the reach of children

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