Rolac 10 mg (Tablet)
Unit Price: ৳ 12.00 (4 x 14: ৳ 672.00)
Strip Price: ৳ 168.00
Medicine Details
| Category | Details |
|---|---|
| Generic | Ketorolac tromethamine |
| Company | Renata limited |
| Also available as |
Indications
- Short-term management of moderate to severe acute post-operative pain
- Relief of pain, inflammation, and light sensitivity after ocular surgery
- Decreasing eye inflammation or redness caused by seasonal allergies
Description
- Belongs to the pyrrolo-pyrrole group of nonsteroidal anti-inflammatory drug (NSAID)
- Chemical name: 5 benzoyle-2,3-dihydro-1H-pyrroligine-1-carboxylic acid, compound with 2-amino-2-(hydroxymethyl)-1,3-propanediol (1:1)
- Inhibits synthesis of prostaglandins
- Pharmacokinetic property: linear
- Highly protein bound
- Largely metabolized in liver
- Excretion in the urine
Pharmacology
- Potent analgesic of the non-steroidal anti-inflammatory drugs (NSAIDs)
- Inhibits cyclooxygenase enzyme system
- Minimal anti-inflammatory effect at analgesic dose
Dosage & Administration
- Tablet recommended dose: 10 mg every 4-6 hours
- Tablet short-term use only (up to 7 days)
- Injection for management of moderately severe, acute pain
- IV bolus administration over no less than 15 seconds
- IM administration given slowly and deeply into the muscle
- Onset of analgesic effect within 30 minutes
- Maximum effect in 1 to 2 hours after dosing IV or IM
- Duration of analgesic effect: 4 to 6 hours
Interaction
- Other NSAIDs or aspirin increase side effects
- Anti-coagulants enhance anti-coagulant effect
- Beta Blocker reduces anti-hypertensive effect
- ACE Inhibitors increase risk of renal impairment
- Methotrexate enhances toxicity of methotrexate
Contraindications
- Hypersensitivity to this drug or other NSAIDs
- Not recommended for use in children under 16 years of age
- Contraindicated as prophylactic analgesic before surgery
Side Effects
- Nausea
- Vomiting
- Gastro-intestinal bleeding
- Melana
- Peptic ulcer
- Pancreatitis
- Anxiety
- Drowsiness
- Headache
- Excessive thirst
- Fatigue
- Bradycardia
- Hypertension
- Palpitation
- Chest pain
- Infertility in female
- Pulmonary edema
Pregnancy & Lactation
- Pregnancy category: C
- Avoid in pregnancy and lactation unless benefits outweigh risks to the fetus
Precautions & Warnings
- Caution in patients over the age of 65 years
- Caution in patients with active or suspected peptic ulcer or gastrointestinal bleeding
- Caution in patients with asthma and liver dysfunction
- Caution in patients with evidence of corneal epithelial breakdown when using eye drops
- Monitoring for corneal health when using topical NSAIDs
- Avoid administering eye drops while wearing contact lenses
Therapeutic Class
- Rheumatoid Arthritis drugs
- Non-Opioid Analgesics
Storage Conditions
- Keep in a dry place away from light and heat
- Keep out of the reach of children