Domilux 10 mg (Tablet)
Unit Price: ৳ 4.00 (7 x 20: ৳ 560.00)
Strip Price: ৳ 80.00
Medicine Details
| Category | Details |
|---|---|
| Generic | Domperidone maleate |
| Company | Popular pharmaceuticals ltd |
| Also available as |
Title
- Domilux 10 mg Tablet
Categories
- Medicine
- Pharmaceuticals
Description
- Dyspeptic symptom relief
- Treatment for delayed gastric emptying
- Management of gastroesophageal reflux
- Control of esophagitis
- Acute nausea and vomiting management
- Parkinson's disease symptom relief
- Facilitates gastric emptying
- Enhances antral and duodenal peristalsis
- Regulates contraction of the pylorus
- Increases esophageal peristalsis
- Restores normal motility of the upper gastrointestinal tract
- Majorly affects the Chemoreceptor Trigger Zone (CTZ) and stomach
Dosage
- Adult dose: 10-20 mg every 6-8 hours
- Adult rectal dose: 30-60 mg every 4-8 hours
- Maximum daily dose for adults: 80 mg
- Pediatric dose based on body weight
- Administration 15-30 minutes before meals
- Duration of treatment in acute nausea and vomiting: maximum 12 weeks
Interaction
- Potential antagonism with anticholinergic drugs
- Oral bioavailability lowered when given with antacids and antisecretory drugs
- Metabolized through CYP3A4 pathway
- Inhibitors of CYP3A4 may increase plasma levels of domperidone
- Minor influence on drugs already stabilized like digoxin and paracetamol
- Does not potentiate the action of neuroleptics or dopaminergic agonists
Contraindications
- Hypersensitivity to the drug
- Neonates
- Gastrointestinal hemorrhage
- Mechanical obstruction or perforation
- Prolactin releasing pituitary tumor (prolactinoma)
Side Effects
- Transient intestinal cramps
- Rare extrapyramidal phenomena
- Possible increase in plasma prolactin level
- Rare allergic reactions like rash and urticaria
Pregnancy & Lactation
- Should be justified in the first trimester of pregnancy
- No evidence of increased risk of malformations in humans
- Excreted in breast milk
- Not recommended for nursing mothers unless benefits outweigh risks
Precautions & Warnings
- Caution in children due to risk of extra-pyramidal reactions
- Caution in patients with hepatic impairment
Use in Special Populations
- Caution required in infants due to immature blood-brain barrier
- Caution in patients with liver or severe renal insufficiency
Overdose Effects
- Symptoms may include drowsiness, disorientation, extrapyramidal reactions
- Recommendation of activated charcoal and close observation
Therapeutic Class
- Motility Stimulants
- Dopamine antagonist
- Prokinetic drugs
Storage Conditions
- Store below 30°C
- Protected from light & moisture
Chemical Structure
- Molecular Formula: C22H24ClN5O2
- Chemical Structure Image: https://medex.com.bd/storage/res/g-res-380-domperidone-maleate-chemical-structure-4Q6P0Z8laWrV7xnOkSMm.svg
Common Questions about Domilux 10 mg Tablet
- Used to treat nausea and vomiting
- Relieves indigestion
- Should be taken before meals as per doctor's prescription
- Caution required when consuming alcohol
- Dizziness and sleepiness may occur