Romilac 30 mg/ml (IM/IV Injection)
1 ml pre-filled syringe: ৳ 80.00
Medicine Details
| Category | Details |
|---|---|
| Generic | Ketorolac tromethamine |
| Company | Techno drugs ltd |
| Also available as |
Indications
- Short-term management of post-operative pain
- Relief from pain and inflammation after ocular surgery
- Decrease in eye inflammation caused by allergies
Description
- Belongs to the pyrrolo-pyrrole group of NSAIDs
- Chemical name: 5 benzoyle-2,3-dihydro-1H-pyrroligine-1-carboxylic acid, compound with 2 - amino-2-(hydroxymethyl)-1,3-propanediol (1:1)
- Inhibits synthesis of prostaglandins
- Biological activity associated with the S-form
- Linear pharmacokinetic property
- Highly protein bound
- Largely metabolized in the liver
- Metabolites and unchanged drugs excreted in urine
Pharmacology
- Potent analgesic NSAID
- Inhibits cyclooxygenase enzyme system
- Minimal anti-inflammatory effect at analgesic dose
Dosage & Administration
- Tablet recommended dose: 10 mg every 4-6 hours
- Injection recommended dose: Varies with age and route of administration
- Eye Drops recommended dose: 1 drop in each eye 4 times daily
- Special dosing considerations for different age groups and patient conditions
- Maximum daily dose limits for different patient categories
Interaction
- Increased side effects with other NSAIDs or aspirin
- Enhanced anti-coagulant effect with anti-coagulants
- Reduced anti-hypertensive effect with beta blockers
- Increased risk of renal impairment with ACE inhibitors
- Enhanced toxicity of methotrexate
Contraindications
- Hypersensitivity to Ketorolac or other NSAIDs
- Children under 16 years of age
- Prophylactic analgesic use before surgery
Side Effects
- Nausea
- Vomiting
- Gastro-intestinal bleeding
- Melena
- Peptic ulcer
- Pancreatitis
- Anxiety
- Drowsiness
- Headache
- Excessive thirst
- Fatigue
- Bradycardia
- Hypertension
- Palpitation
- Chest pain
- Infertility in females
- Pulmonary edema
Pregnancy & Lactation
- FDA Pregnancy category C
- Avoid use in pregnancy and lactation unless benefits outweigh risks
Precautions & Warnings
- Caution in patients over 65 years
- Caution in patients with peptic ulcer, gastrointestinal bleeding, asthma, liver dysfunction
- Discontinue use for corneal epithelial breakdown
- Monitoring of corneal health
- Avoid administration while wearing contact lenses
Therapeutic Class
- Drugs used for Rheumatoid Arthritis
- Non-Opioid Analgesics
Storage Conditions
- Store in a dry place away from light and heat
- Keep out of the reach of children