Rotalac 30 mg/ml (IM/IV Injection)
1 ml ampoule: ৳ 55.00
Medicine Details
| Category | Details |
|---|---|
| Generic | Ketorolac tromethamine |
| Company | Pharmasia limited |
| Also available as |
Indications
- Management of moderate to severe acute post-operative pain
- Relief of pain, inflammation, and light sensitivity after ocular surgery
- Decrease eye inflammation or redness caused by seasonal allergies
Description
- Drug of pyrrolo-pyrrole group of nonsteroidal anti-inflammatory drug (NSAID)
- Chemical composition: 5 benzoyle-2,3-dihydro-1H-pyrroligine-1-carboxylic acid, compound with 2 - amino-2-(hydroxymethyl)-1,3-propanediol (1:1)
- Inhibits synthesis of prostaglandins
- Associated with the S-form
- Metabolized in the liver
- Metabolism products excreted in the urine
Pharmacology
- Potent analgesic of the non-steroidal anti-inflammatory drugs (NSAIDs)
- Inhibits cyclooxygenase enzyme system
- Minimal anti-inflammatory effect at analgesic dose
Dosage & Administration
- Tablet recommended dose: 10 mg every 4-6 hours for short-term use (up to 7 days)
- Injection recommended for management of moderately severe, acute pain
- IV bolus administration over no less than 15 seconds
- IM administration given slowly and deeply into the muscle
- Onset of analgesic effect within 30 minutes
- Maximum analgesic effect in 1 to 2 hours
- Duration of analgesic effect usually 4 to 6 hours
- Eye Drops: Adults - 1 drop in each eye 4 times daily
Interaction
- Other NSAIDs or aspirin: Increase side effects
- Anti-coagulants: Enhance anti-coagulant effect
- Beta Blocker: Reduce anti-hypertensive effect
- ACE Inhibitors: Increase risk of renal impairment
- Methotrexate: Enhance toxicity of methotrexate
Contraindications
- Hypersensitivity to drug or other NSAIDs
- Not to be used in children under 16 years of age
- Contraindicated as prophylactic analgesic before surgery
Side Effects
- Nausea
- Vomiting
- Gastro-intestinal bleeding
- Melana
- Peptic ulcer
- Pancreatitis
- Anxiety
- Drowsiness
- Headache
- Excessive thirst
- Fatigue
- Bradycardia
- Hypertension
- Palpitation
- Chest pain
- Infertility in female
- Pulmonary edema
Pregnancy & Lactation
- US FDA Pregnancy category: C
- Avoid in pregnancy and lactation unless potential benefits to the mother outweigh the possible risks to the fetus
Precautions & Warnings
- Caution in patients over the age of 65 years
- Caution in patients with active or suspected peptic ulcer or gastrointestinal bleeding
- Caution in patients with asthma and liver dysfunction
- Discontinue use of topical NSAIDs in patients with corneal epithelial breakdown
Therapeutic Class
- Drugs used for Rheumatoid Arthritis
- Non-Opioid Analgesics
Storage Conditions
- Keep in a dry place away from light and heat
- Keep out of the reach of children