Rotek 10 mg (Tablet)

Unit Price: ৳ 10.00 (30's pack: ৳ 300.00)

Medicine Details

Category Details
Generic Ketorolac tromethamine
Company Novo healthcare and pharma ltd
Also available as
Rotek 30 mg injection

Indications

  • Short-term management of moderate to severe acute post-operative pain
  • Relieves pain, inflammation, and light sensitivity after ocular surgery
  • Decreases eye inflammation or redness caused by seasonal allergies

Description

  • Belongs to the pyrrolo-pyrrole group of nonsteroidal anti-inflammatory drugs (NSAID)
  • Chemical composition: 5 benzoyle-2,3-dihydro-1H-pyrroligine-1-carboxylic acid, compound with 2 - amino-2-(hydroxymethyl)-1,3-propanediol (1:1)
  • Inhibits the synthesis of prostaglandins and acts as a peripherally acting analgesic
  • Biological activity associated with the S-form
  • Linear pharmacokinetic property
  • Highly protein bound
  • Metabolized in the liver
  • Products of metabolism and some unchanged drugs are excreted in the urine

Pharmacology

  • Potent analgesic of the non-steroidal anti-inflammatory drugs (NSAIDs)
  • Inhibits the cyclooxygenase enzyme system and prostaglandin synthesis
  • Demonstrates minimal anti-inflammatory effect at analgesic dose

Dosage & Administration

  • Tablet recommended dose: 10 mg every 4-6 hours for short-term use only (up to 7 days)
  • Injection may be used for the management of moderately severe, acute pain
  • Recommended IM and IV doses for different age groups and conditions
  • Maximum daily dose limits for different populations
  • Eye drops dosage: 1 drop in each eye 4 times daily

Interaction

  • Other NSAIDs or aspirin increase the side effects of Rotek
  • Anti-coagulants enhance anti-coagulant effect
  • Beta Blocker reduces the anti-hypertensive effect
  • ACE Inhibitors increase the risk of renal impairment
  • Methotrexate enhances the toxicity of methotrexate

Contraindications

  • Hypersensitivity to the drug or other NSAIDs
  • Not to be used in children under 16 years of age
  • Contraindicated as prophylactic analgesic before surgery

Side Effects

  • Nausea
  • Vomiting
  • Gastro-intestinal bleeding
  • Melana
  • Peptic ulcer
  • Pancreatitis
  • Anxiety
  • Drowsiness
  • Headache
  • Excessive thirst
  • Fatigue
  • Bradycardia
  • Hypertension
  • Palpitation
  • Chest pain
  • Infertility in females
  • Pulmonary edema

Pregnancy & Lactation

  • US FDA Pregnancy category: C
  • Avoid in pregnancy and lactation unless potential benefits outweigh possible risks to the fetus

Precautions & Warnings

  • Exercise caution in patients over the age of 65 years
  • Also caution in patients with active or suspected peptic ulcer, gastrointestinal bleeding, asthma, and liver dysfunction
  • Patients with evidence of corneal epithelial breakdown should discontinue use of topical NSAIDs and be closely monitored for corneal health
  • Lopadol ophthalmic solution should not be administered while wearing contact lenses

Therapeutic Class

  • Drugs used for Rheumatoid Arthritis
  • Non-Opioid Analgesics

Storage Conditions

  • Store in a dry place away from light and heat
  • Keep out of the reach of children

Related Brands