Toro 10 mg (Tablet)
Unit Price: ৳ 10.00 (20's pack: ৳ 200.00)
Medicine Details
| Category | Details |
|---|---|
| Generic | Ketorolac tromethamine |
| Company | Amulet pharmaceuticals ltd |
| Also available as |
Indications
- Short-term management of moderate to severe acute post-operative pain
- Relief of pain, inflammation, and light sensitivity after ocular surgery
- Decrease eye inflammation or redness caused by seasonal allergies
Description
- Belongs to the pyrrolo-pyrrole group of nonsteroidal anti-inflammatory drugs (NSAID)
- Chemical name: 5 benzoyle-2,3-dihydro-1H-pyrroligine-1-carboxylic acid, compound with 2 - amino-2-(hydroxymethyl)-1,3-propanediol (1:1)
- Inhibits synthesis of prostaglandins
- Biological activity associated with the S-form
- Pharmacokinetic property is linear
- Highly protein bound
- Largely metabolized in the liver
- Metabolites and some unchanged drugs excreted in the urine
Pharmacology
- Potent analgesic of the non-steroidal anti-inflammatory drugs (NSAIDs)
- Acts by inhibiting the cyclooxygenase enzyme system
- Demonstrates minimal anti-inflammatory effect at its analgesic dose
Dosage & Administration
- Tablet: Recommended dose is 10 mg every 4-6 hours for up to 7 days
- Injection: Used for moderately severe, acute pain management postoperatively
- IV bolus must be given over no less than 15 seconds
- IM administration given slowly and deeply into the muscle
- Onset of analgesic effect within 30 minutes
- Maximum effect in 1 to 2 hours
- Duration of analgesic effect is usually 4 to 6 hours
- Various dosing for different patient categories
Interaction
- Other NSAIDs or aspirin increase the side effects of Ketorolac Tromethamine
- Anti-coagulants enhance anti-coagulant effect
- Beta Blocker reduces the anti-hypertensive effect
- ACE Inhibitors increase the risk of renal impairment
- Methotrexate enhances the toxicity of methotrexate
Contraindications
- Hypersensitivity to Ketorolac or other NSAIDs
- Not for use in children under 16 years
- Contraindicated as prophylactic analgesic before surgery
Side Effects
- Nausea
- Vomiting
- Gastro-intestinal bleeding
- Melena
- Peptic ulcer
- Pancreatitis
- Anxiety
- Drowsiness
- Headache
- Excessive thirst
- Fatigue
- Bradycardia
- Hypertension
- Palpitation
- Chest pain
- Infertility in females
- Pulmonary edema
Pregnancy & Lactation
- US FDA Pregnancy category of Ketorolac Tromethamine is C
- Avoid in pregnancy and lactation unless potential benefits outweigh possible risks to the fetus
Precautions & Warnings
- Caution in patients over 65 years
- Caution in patients with active or suspected peptic ulcer, gastrointestinal bleeding, asthma, and liver dysfunction
- Special precautions for use of ophthalmic solution in patients with corneal epithelial breakdown and those wearing contact lenses
Therapeutic Class
- Rheumatoid Arthritis
- Non-Opioid Analgesics
Storage Conditions
- Keep in a dry place away from light and heat
- Keep out of the reach of children