Toroaid 30 mg/ml (IM/IV Injection)
1 ml ampoule: ৳ 55.23 (1 x 5: ৳ 276.14)
Medicine Details
| Category | Details |
|---|---|
| Generic | Ketorolac tromethamine |
| Company | General pharmaceuticals ltd |
| Also available as |
Indications
- Short-term management of moderate to severe acute post-operative pain
- Relief of pain, inflammation, and light sensitivity after ocular surgery
- Decrease eye inflammation or redness caused by seasonal allergies
Drug Class
- Nonsteroidal anti-inflammatory drug (NSAID)
- Drugs used for Rheumatoid Arthritis
- Non-Opioid Analgesics
Description
- Chemical composition: 5 benzoyle-2,3-dihydro-1H-pyrroligine-1-carboxylic acid, compound with 2 - amino-2-(hydroxymethyl)-1,3-propanediol (1:1)
- Biological activity associated with the S-form
- Linear pharmacokinetic properties
- Highly protein bound and largely metabolized in the liver
- Metabolites and unchanged drugs excreted in the urine
Mode of Action
- Inhibition of cyclooxygenase enzyme system
- Inhibition of prostaglandin synthesis
- Minimal anti-inflammatory effect at analgesic dose
Dosage & Administration
- Tablet: Recommended dose is 10 mg every 4-6 hours for short-term use (up to 7 days)
- Injection: Single or multiple doses for acute pain management, with specific dosing guidelines for different patient populations and age groups
- Eye Drops: Recommended administration frequency of 1 drop in each eye 4 times daily
Interaction
- Increased side effects with other NSAIDs or aspirin
- Enhanced anti-coagulant effect with anti-coagulants
- Reduced anti-hypertensive effect with Beta Blocker
- Increased risk of renal impairment with ACE Inhibitors
- Enhanced toxicity of methotrexate
Contraindications
- Hypersensitivity to Ketorolac or other NSAIDs
- Use in children under 16 years of age
- Prophylactic use before surgery
Side Effects
- Nausea
- Vomiting
- Gastro-intestinal bleeding
- Melena
- Peptic ulcer
- Pancreatitis
- Anxiety
- Drowsiness
- Headache
- Excessive thirst
- Fatigue
- Bradycardia
- Hypertension
- Palpitation
- Chest pain
- Infertility in females
- Pulmonary edema
Pregnancy & Lactation
- US FDA Pregnancy category: C
- Avoidance of use in pregnancy and lactation unless benefits outweigh risks
Precautions & Warnings
- Caution in patients over 65 years old
- Caution in patients with active or suspected peptic ulcer, gastrointestinal bleeding, asthma, and liver dysfunction
- Immediate discontinuation and close monitoring in case of corneal epithelial breakdown with Eye Drops
- Avoidance of administration while wearing contact lenses with Eye Drops
Storage Conditions
- Dry place away from light and heat
- Keep out of the reach of children