Toroaid 30 mg/ml (IM/IV Injection)

1 ml ampoule: ৳ 55.23 (1 x 5: ৳ 276.14)

Medicine Details

Category Details
Generic Ketorolac tromethamine
Company General pharmaceuticals ltd
Also available as
Toroaid 10 mg tablet Toroaid 05 eye drop Toroaid 60 mg injection

Indications

  • Short-term management of moderate to severe acute post-operative pain
  • Relief of pain, inflammation, and light sensitivity after ocular surgery
  • Decrease eye inflammation or redness caused by seasonal allergies

Drug Class

  • Nonsteroidal anti-inflammatory drug (NSAID)
  • Drugs used for Rheumatoid Arthritis
  • Non-Opioid Analgesics

Description

  • Chemical composition: 5 benzoyle-2,3-dihydro-1H-pyrroligine-1-carboxylic acid, compound with 2 - amino-2-(hydroxymethyl)-1,3-propanediol (1:1)
  • Biological activity associated with the S-form
  • Linear pharmacokinetic properties
  • Highly protein bound and largely metabolized in the liver
  • Metabolites and unchanged drugs excreted in the urine

Mode of Action

  • Inhibition of cyclooxygenase enzyme system
  • Inhibition of prostaglandin synthesis
  • Minimal anti-inflammatory effect at analgesic dose

Dosage & Administration

  • Tablet: Recommended dose is 10 mg every 4-6 hours for short-term use (up to 7 days)
  • Injection: Single or multiple doses for acute pain management, with specific dosing guidelines for different patient populations and age groups
  • Eye Drops: Recommended administration frequency of 1 drop in each eye 4 times daily

Interaction

  • Increased side effects with other NSAIDs or aspirin
  • Enhanced anti-coagulant effect with anti-coagulants
  • Reduced anti-hypertensive effect with Beta Blocker
  • Increased risk of renal impairment with ACE Inhibitors
  • Enhanced toxicity of methotrexate

Contraindications

  • Hypersensitivity to Ketorolac or other NSAIDs
  • Use in children under 16 years of age
  • Prophylactic use before surgery

Side Effects

  • Nausea
  • Vomiting
  • Gastro-intestinal bleeding
  • Melena
  • Peptic ulcer
  • Pancreatitis
  • Anxiety
  • Drowsiness
  • Headache
  • Excessive thirst
  • Fatigue
  • Bradycardia
  • Hypertension
  • Palpitation
  • Chest pain
  • Infertility in females
  • Pulmonary edema

Pregnancy & Lactation

  • US FDA Pregnancy category: C
  • Avoidance of use in pregnancy and lactation unless benefits outweigh risks

Precautions & Warnings

  • Caution in patients over 65 years old
  • Caution in patients with active or suspected peptic ulcer, gastrointestinal bleeding, asthma, and liver dysfunction
  • Immediate discontinuation and close monitoring in case of corneal epithelial breakdown with Eye Drops
  • Avoidance of administration while wearing contact lenses with Eye Drops

Storage Conditions

  • Dry place away from light and heat
  • Keep out of the reach of children

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