Tram-K 10 mg (Tablet)
Unit Price: ৳ 10.00 (20's pack: ৳ 200.00)
Medicine Details
| Category | Details |
|---|---|
| Generic | Ketorolac tromethamine |
| Company | Mst pharma |
Indications
- Short-term management of post-operative pain
- Relieves pain, inflammation, and light sensitivity after ocular surgery
- Reduces eye inflammation or redness caused by seasonal allergies
Description
- Belongs to the pyrrolo-pyrrole group of nonsteroidal anti-inflammatory drug (NSAID)
- Chemical name: 5 benzoyle-2,3-dihydro-1H-pyrroligine-1-carboxylic acid, compound with 2 - amino-2-(hydroxymethyl)-1,3-propanediol (1:1)
- Inhibits synthesis of prostaglandins as a peripherally acting analgesic
- Biologically active form: S-form
- Linear pharmacokinetic property
- Highly protein bound and largely metabolized in the liver
- Metabolites and some unchanged drugs are excreted in the urine
Pharmacology
- Potent analgesic among non-steroidal anti-inflammatory drugs (NSAIDs)
- Inhibits cyclooxygenase enzyme system and prostaglandin synthesis
- Demonstrates minimal anti-inflammatory effect at analgesic dose
Dosage & Administration
- Tablet: Recommended dose is 10 mg every 4-6 hours for up to 7 days
- Injection: Single or multiple doses for moderately severe, acute pain
- Eye Drops: 1 drop in each eye 4 times daily
Interaction
- Other NSAIDs or aspirin: Increases side effects
- Anti-coagulants: Enhances anti-coagulant effect
- Beta Blocker: Reduces the anti-hypertensive effect
- ACE Inhibitors: Increases the risk of renal impairment
- Methotrexate: Enhances the toxicity of methotrexate
Contraindications
- Hypersensitivity to Ketorolac or other NSAIDs
- Children under 16 years of age
- Prophylactic analgesic before surgery
Side Effects
- Nausea, vomiting
- Gastro-intestinal bleeding, melana, peptic ulcer, pancreatitis
- Anxiety, drowsiness, headache, excessive thirst, fatigue
- Bradycardia, hypertension, palpitation, chest pain
- Infertility in females, pulmonary edema
Pregnancy & Lactation
- Ketorolac Tromethamine is FDA Pregnancy category C
- Avoid in pregnancy and lactation unless potential benefits outweigh possible risks to the fetus
Precautions & Warnings
- Caution in patients over 65 years, with active or suspected peptic ulcer or gastrointestinal bleeding, asthma, and liver dysfunction
- Discontinue use of topical NSAIDs and monitor corneal health in patients with corneal epithelial breakdown
- Avoid administering while wearing contact lenses
Therapeutic Class
- Non-Opioid Analgesics, Drugs used for Rheumatoid Arthritis
Storage Conditions
- Keep in a dry place away from light and heat
- Keep out of the reach of children