Tram-K 10 mg (Tablet)

Unit Price: ৳ 10.00 (20's pack: ৳ 200.00)

Medicine Details

Category Details
Generic Ketorolac tromethamine
Company Mst pharma

Indications

  • Short-term management of post-operative pain
  • Relieves pain, inflammation, and light sensitivity after ocular surgery
  • Reduces eye inflammation or redness caused by seasonal allergies

Description

  • Belongs to the pyrrolo-pyrrole group of nonsteroidal anti-inflammatory drug (NSAID)
  • Chemical name: 5 benzoyle-2,3-dihydro-1H-pyrroligine-1-carboxylic acid, compound with 2 - amino-2-(hydroxymethyl)-1,3-propanediol (1:1)
  • Inhibits synthesis of prostaglandins as a peripherally acting analgesic
  • Biologically active form: S-form
  • Linear pharmacokinetic property
  • Highly protein bound and largely metabolized in the liver
  • Metabolites and some unchanged drugs are excreted in the urine

Pharmacology

  • Potent analgesic among non-steroidal anti-inflammatory drugs (NSAIDs)
  • Inhibits cyclooxygenase enzyme system and prostaglandin synthesis
  • Demonstrates minimal anti-inflammatory effect at analgesic dose

Dosage & Administration

  • Tablet: Recommended dose is 10 mg every 4-6 hours for up to 7 days
  • Injection: Single or multiple doses for moderately severe, acute pain
  • Eye Drops: 1 drop in each eye 4 times daily

Interaction

  • Other NSAIDs or aspirin: Increases side effects
  • Anti-coagulants: Enhances anti-coagulant effect
  • Beta Blocker: Reduces the anti-hypertensive effect
  • ACE Inhibitors: Increases the risk of renal impairment
  • Methotrexate: Enhances the toxicity of methotrexate

Contraindications

  • Hypersensitivity to Ketorolac or other NSAIDs
  • Children under 16 years of age
  • Prophylactic analgesic before surgery

Side Effects

  • Nausea, vomiting
  • Gastro-intestinal bleeding, melana, peptic ulcer, pancreatitis
  • Anxiety, drowsiness, headache, excessive thirst, fatigue
  • Bradycardia, hypertension, palpitation, chest pain
  • Infertility in females, pulmonary edema

Pregnancy & Lactation

  • Ketorolac Tromethamine is FDA Pregnancy category C
  • Avoid in pregnancy and lactation unless potential benefits outweigh possible risks to the fetus

Precautions & Warnings

  • Caution in patients over 65 years, with active or suspected peptic ulcer or gastrointestinal bleeding, asthma, and liver dysfunction
  • Discontinue use of topical NSAIDs and monitor corneal health in patients with corneal epithelial breakdown
  • Avoid administering while wearing contact lenses

Therapeutic Class

  • Non-Opioid Analgesics, Drugs used for Rheumatoid Arthritis

Storage Conditions

  • Keep in a dry place away from light and heat
  • Keep out of the reach of children

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