Xenolac 10 mg (Tablet)

Unit Price: ৳ 10.00 (20's pack: ৳ 200.00)

Medicine Details

Category	Details
Generic	Ketorolac tromethamine
Company	Marker pharma ltd

Indications

Short-term management of moderate to severe acute post-operative pain
Relieves pain, inflammation, and light sensitivity after ocular surgery
Decreases eye inflammation or redness caused by seasonal allergies

Drug Group

Pyrrolo-pyrrole group of nonsteroidal anti-inflammatory drug (NSAID)

Chemical Composition

5 benzoyle-2,3-dihydro-1H-pyrroligine-1-carboxylic acid, compound with 2 - amino-2-(hydroxymethyl)-1,3-propanediol (1:1)

Biological Activity

Associated with the S-form

Pharmacokinetic Property

Linear, highly protein bound, largely metabolized in the liver

Mode of Action

Inhibits synthesis of prostaglandins, acts as a peripherally acting analgesic, minimal anti-inflammatory effect at analgesic dose

Tablet Dosage

Recommended dose is 10 mg every 4-6 hours, short-term use only (up to 7 days)

Injection Dosage

IV bolus to be given over no less than 15 seconds
IM administration should be given slowly and deeply into the muscle
Onset of analgesic effect within 30 minutes, maximum effect in 1 to 2 hours after dosing IV or IM
Duration of analgesic effect is usually 4 to 6 hours
Different doses for different age groups and conditions for single and multiple dose treatments
Total combined daily dose of ketorolac (oral + parenteral) should not exceed 120 mg in younger adult patients or 60 mg in elderly patients on the day the change of formulation is made
Total duration of combined parenteral and oral treatment should not exceed 5 days

Eye Drops Dosage

Adults: 1 drop in each eye 4 times daily

Drug Interactions

Increased side effects with other NSAIDs or aspirin
Enhanced anti-coagulant effect with anti-coagulants
Reduced anti-hypertensive effect with Beta Blockers
Increased risk of renal impairment with ACE Inhibitors
Enhanced toxicity of methotrexate

Contraindications

Hypersensitivity to ketorolac or other NSAIDs
Children under 16 years of age
Prophylactic analgesic before surgery

Side Effects

Nausea
Vomiting
Gastro-intestinal bleeding
Melena
Peptic ulcer
Pancreatitis
Anxiety
Drowsiness
Headache
Excessive thirst
Fatigue
Bradycardia
Hypertension
Palpitation
Chest pain
Infertility in females
Pulmonary edema

Pregnancy and Lactation

Category C drug, should be avoided unless benefits outweigh risks

Precautions and Warnings

Exercise caution in patients over the age of 65 years
Caution in patients with active or suspected peptic ulcer, gastrointestinal bleeding, asthma, and liver dysfunction
Patients with evidence of corneal epithelial breakdown should discontinue use of topical NSAIDs and be closely monitored for corneal health
Eye Drops should not be administered while wearing contact lenses