Xidolac 10 mg (Tablet)

Unit Price: ৳ 10.00 (2 x 10: ৳ 200.00)
Strip Price: ৳ 100.00

Medicine Details

Category Details
Generic Ketorolac tromethamine
Company Beximco pharmaceuticals ltd
Also available as
Xidolac 10 mg injection Xidolac 30 mg injection Xidolac meltab 10 mg tablet

Title

  • Xidolac

Categories

  • Nonsteroidal Anti-Inflammatory Drug (NSAID)
  • Ophthalmic Solution
  • Pain Relief Medication
  • Analgesic Drug
  • Non-Opioid Analgesic
  • Rheumatoid Arthritis Medication
  • Post-Operative Pain Relief

Indications

  • Management of moderate to severe acute post-operative pain
  • Relief of pain, inflammation, and light sensitivity after ocular surgery
  • Reduction of eye inflammation or redness caused by seasonal allergies

Description

  • Belongs to the pyrrolo-pyrrole group of NSAIDs
  • Chemical name: 5-benzoyle-2,3-dihydro-1H-pyrroligine-1-carboxylic acid compound with 2-amino-2-(hydroxymethyl)-1,3-propanediol (1:1)
  • Inhibits synthesis of prostaglandins
  • Considered a peripherally acting analgesic
  • Biological activity associated with the S-form
  • Linear pharmacokinetic property
  • Highly protein bound
  • Metabolized in the liver
  • Metabolites and some unchanged drugs excreted in the urine

Mode Of Action

  • Inhibits the cyclooxygenase enzyme system
  • Minimal anti-inflammatory effect at analgesic dose

Dosage & Administration

  • Tablet recommended dose: 10 mg every 4-6 hours, short-term use only
  • Injection for moderately severe acute pain management
  • IV bolus administration over no less than 15 seconds
  • IM administration should be given slowly and deeply into the muscle
  • Maximum analgesic effect within 30 minutes to 2 hours after dosing
  • Duration of analgesic effect is usually 4 to 6 hours
  • Different dosing regimens based on age, weight, and route of administration
  • Eye Drops: 1 drop in each eye 4 times daily

Interaction

  • Increased side effects with other NSAIDs or aspirin
  • Enhanced anti-coagulant effect with anti-coagulants
  • Reduced anti-hypertensive effect with Beta Blockers
  • Increased risk of renal impairment with ACE Inhibitors
  • Enhanced toxicity of methotrexate

Contraindications

  • Hypersensitivity to Ketorolac or other NSAIDs
  • Use not recommended in children under 16 years of age
  • Contraindicated as prophylactic analgesic before surgery

Side Effects

  • Nausea
  • Vomiting
  • Gastrointestinal bleeding
  • Melena
  • Peptic ulcer
  • Pancreatitis
  • Anxiety
  • Drowsiness
  • Headache
  • Excessive thirst
  • Fatigue
  • Bradycardia
  • Hypertension
  • Palpitation
  • Chest pain
  • Infertility in females
  • Pulmonary edema

Pregnancy & Lactation

  • US FDA Pregnancy category C
  • Avoided in pregnancy and lactation unless benefits outweigh risks to the fetus

Precautions & Warnings

  • Caution in patients over 65 years of age
  • Caution in patients with active or suspected peptic ulcer, gastrointestinal bleeding, asthma, or liver dysfunction
  • Discontinue use of topical NSAIDs in patients with evidence of corneal epithelial breakdown, monitor for corneal health
  • Avoid administration of ophthalmic solution while wearing contact lenses

Therapeutic Class

  • Used for Rheumatoid Arthritis
  • Non-Opioid Analgesics

Storage Conditions

  • Keep in a dry place
  • Away from light and heat
  • Keep out of the reach of children

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