Xidolac 10 mg/ml (IM/IV Injection)
1 ml ampoule: ৳ 30.00 (1 x 5: ৳ 150.00)
Medicine Details
| Category | Details |
|---|---|
| Generic | Ketorolac tromethamine |
| Company | Beximco pharmaceuticals ltd |
| Also available as |
Indications
- Short-term management of moderate to severe acute post-operative pain
- Relieves pain, inflammation, and light sensitivity after ocular surgery
- Decreases eye inflammation or redness caused by seasonal allergies
Description
- Belongs to the pyrrolo-pyrrole group of nonsteroidal anti-inflammatory drugs (NSAID)
- Chemical name: 5 benzoyle-2,3-dihydro-1H-pyrroligine-1-carboxylic acid, compound with 2-amino-2-(hydroxymethyl)-1,3-propanediol (1:1)
- Inhibits synthesis of prostaglandins and acts as a peripherally acting analgesic
- Highly protein bound and largely metabolized in the liver
Pharmacology
- Inhibits the cyclooxygenase enzyme system
- Demonstrates minimal anti-inflammatory effect at its analgesic dose
Dosage & Administration
- Tablet recommended dose: 10 mg every 4-6 hours for short-term use up to 7 days
- Injection recommended dose: variances by age, weight, and method of administration
Interaction
- Other NSAIDs or aspirin: Increase the side effects
- Anti-coagulants: Enhance anti-coagulant effect
- Beta Blocker: Reduce the anti-hypertensive effect
- ACE Inhibitors: Increase the risk of renal impairment
- Methotrexate: Enhance the toxicity of methotrexate
Contraindications
- Hypersensitivity to ketorolac or other NSAIDs
- Use in children under 16 years of age
- Contradicted as prophylactic analgesic before surgery
Side Effects
- Nausea
- Vomiting
- Gastro-intestinal bleeding
- Headache
- Fatigue
- Hypertension
- Infertility in female
- Pulmonary edema
Pregnancy & Lactation
- US FDA Pregnancy category: C
- Avoid in pregnancy and lactation unless benefits outweigh risks to the fetus
Precautions & Warnings
- Exercise caution in patients over the age of 65 years
- Caution in patients with active or suspected peptic ulcer, gastrointestinal bleeding, asthma, and liver dysfunction
- Discontinue use of topical NSAIDs in patients with corneal epithelial breakdown
Therapeutic Class
- Rheumatoid Arthritis drugs
- Non-Opioid Analgesics
Storage Conditions
- Keep in a dry place away from light and heat
- Keep out of the reach of children