Domin 5 mg/5 ml (Oral Suspension)

60 ml bottle: ৳ 35.00

Medicine Details

Category Details
Generic Domperidone maleate
Company Opsonin pharma ltd
Also available as
Domin 10 mg tablet Domin 5 mg pediatric drop Domin 30 mg suppository Domin 15 mg suppository

Title

Domin 5 mg/5 ml Suspension

Categories

  • Medicine
  • Pharmaceutical

Description

A dopamine antagonist medication used to treat nausea and vomiting, with indications in dyspeptic symptom complex, acute nausea and vomiting, Parkinson's disease, radiological studies etc.

Color Options

  • Clear liquid form

Physical Form

Liquid

Volume

5 ml per 5 mg

Dosage Form

Suspension

Dosage Administration

    • Adults: 10-20 mg, every 6-8 hours daily
    • Children: 2-4 ml/10 kg body weight, every 6-8 hours daily
    • By Rectum: 30-60 mg every 4-8 hours

Pharmacological Action

Dopamine antagonist, gastroprokinetic action, gastrointestinal motility regulation, enhancing gastric emptying and peristalsis

Contraindications

  • Hypersensitivity to the drug
  • Neonates
  • Gastrointestinal hemorrhage, obstruction or perforation
  • Prolactin releasing pituitary tumor

Interaction

  • Anticholinergic drugs may antagonize effect
  • Antacids and antisecretory drugs lower oral bioavailability
  • Inhibition of CYP3A4 enzyme may increase plasma levels

Side Effects

  • Transient intestinal cramps
  • Rare extrapyramidal phenomena
  • Possible increase in plasma prolactin level
  • Rare allergic reactions such as rash and urticaria

Pregnancy & Lactation

Caution during first trimester, limited excretion in breast milk, not recommended for nursing mothers

Precautions & Warnings

  • Caution in children due to risk of extrapyramidal reactions
  • Caution in hepatic impairment

Special Populations

  • Caution in infants due to immature blood-brain barrier
  • Caution in hepatic impairment
  • Dosage adjustment for renal insufficiency

Overdose Effects

  • Drowsiness, disorientation, extrapyramidal reactions
  • Administration of activated charcoal recommended
  • Anticholinergic drugs may help control extrapyramidal reactions

Therapeutic Class

  • Motility Stimulants
  • Dopamine antagonist
  • Prokinetic drugs

Storage Conditions

Store below 30°C, protected from light & moisture, keep out of children's reach

Chemical Structure

  • Molecular Formula: C22H24ClN5O2
  • Chemical Structure Image: https://medex.com.bd/storage/res/g-res-380-domperidone-maleate-chemical-structure-4Q6P0Z8laWrV7xnOkSMm.svg

Common Questions

  • Usage: Relief of nausea, vomiting, and indigestion
  • Tips:
    • Take before meals as per doctor's prescription
    • May cause dizziness and sleepiness
    • Avoid alcohol consumption
    • Dry mouth may occur as a side effect
    • Consult doctor if symptoms persist beyond 7 days

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