Zeropain 30 mg/ml (IM/IV Injection)

1 ml ampoule: ৳ 60.00 (1 x 5: ৳ 300.00)

Medicine Details

Category Details
Generic Ketorolac tromethamine
Company Healthcare pharmaceuticals ltd
Also available as
Zeropain 10 mg tablet Zeropain 60 mg injection

Indications

  • Management of moderate to severe acute post-operative pain
  • Relief of pain, inflammation, and light sensitivity after ocular surgery
  • Decreasing eye inflammation or redness caused by seasonal allergies

Category

  • Nonsteroidal anti-inflammatory drug (NSAID)
  • Ophthalmic solution
  • Analgesic
  • Anti-inflammatory

Chemical Composition

  • Pyrrolo-pyrrole group
  • 5 benzoyle-2,3-dihydro-1H-pyrroligine-1-carboxylic acid
  • 2-amino-2-(hydroxymethyl)-1,3-propanediol

Pharmacological Action

  • Inhibition of prostaglandin synthesis
  • Minimal anti-inflammatory effect

Dosage & Administration

  • Tablet: 10 mg every 4-6 hours, up to 7 days
  • Injection: Single or multiple doses
  • Eye Drops: 1 drop in each eye 4 times daily

Interaction

  • Increased side effects with other NSAIDs or aspirin
  • Enhanced anti-coagulant effect with anti-coagulants
  • Reduced anti-hypertensive effect with Beta Blockers
  • Increased risk of renal impairment with ACE Inhibitors
  • Enhanced toxicity of methotrexate

Contraindications

  • Hypersensitivity to Ketorolac or other NSAIDs
  • Children under 16 years of age
  • Prophylactic analgesic before surgery

Side Effects

  • Nausea
  • Vomiting
  • Gastro-intestinal bleeding
  • Peptic ulcer
  • Pancreatitis
  • Anxiety
  • Drowsiness
  • Headache
  • Excessive thirst
  • Fatigue
  • Bradycardia
  • Hypertension
  • Palpitation
  • Chest pain
  • Infertility in females
  • Pulmonary edema

Pregnancy & Lactation

  • Pregnancy category C
  • Avoidance in pregnancy and lactation unless benefits outweigh risks

Precautions & Warnings

  • Caution in patients over 65 years of age
  • Caution in patients with peptic ulcer, gastrointestinal bleeding, asthma, and liver dysfunction
  • Discontinue use of topical NSAIDs in patients with corneal epithelial breakdown
  • Avoid administering while wearing contact lenses

Therapeutic Class

  • Drugs used for Rheumatoid Arthritis
  • Non-Opioid Analgesics

Storage Conditions

Keep in a dry place away from light and heat. Keep out of the reach of children.

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