Inket 10 mg (Tablet)
Unit Price: ৳ 10.00 (40's pack: ৳ 400.00)
Medicine Details
| Category | Details |
|---|---|
| Generic | Ketorolac tromethamine |
| Company | Indo bangla pharmaceutical |
Indications
- Short-term management of moderate to severe acute post-operative pain
- Relieve pain, inflammation, and light sensitivity after ocular surgery
- Decrease eye inflammation or redness caused by seasonal allergies
Description
- Belongs to the pyrrolo-pyrrole group of nonsteroidal anti-inflammatory drugs (NSAIDs)
- Chemical name: 5 benzoyle-2,3-dihydro-1H-pyrroligine-1-carboxylic acid, compound with 2-amino-2-(hydroxymethyl)-1,3-propanediol
- Inhibits prostaglandin synthesis as a peripherally acting analgesic
- Biological activity associated with the S-form
- Linear pharmacokinetic property
- Highly protein bound
- Metabolized in the liver
- Excretion in urine
Pharmacology
- Potent analgesic among non-steroidal anti-inflammatory drugs (NSAIDs)
- Inhibits cyclooxygenase enzyme system
- Minimal anti-inflammatory effect at analgesic dose
Dosage & Administration
- Tablet recommended dose: 10 mg every 4-6 hours
- Injection recommended dose: Varies based on age and condition
- Duration of analgesic effect: 4 to 6 hours
- Different dosages for different patient groups
Interaction
- Other NSAIDs or aspirin: Increase side effects
- Anti-coagulants: Enhance anti-coagulant effect
- Beta Blockers: Reduce anti-hypertensive effect
- ACE Inhibitors: Increase risk of renal impairment
- Methotrexate: Enhance toxicity
Contraindications
- Hypersensitivity to the drug or other NSAIDs
- Not for use in children under 16 years
- Contraindicated as prophylactic analgesic before surgery
Side Effects
- Nausea, vomiting, gastro-intestinal bleeding, melena, peptic ulcer
- Pancreatitis, anxiety, drowsiness, headache, excessive thirst
- Fatigue, bradycardia, hypertension, palpitation, chest pain
- Infertility in females, pulmonary edema
Pregnancy & Lactation
- US FDA Pregnancy category C
- Avoid in pregnancy and lactation unless benefits outweigh risks
Precautions & Warnings
- Exercise caution in patients over 65 years
- Caution in patients with peptic ulcer, gastrointestinal bleeding, asthma, liver dysfunction
- Special precautions for patients with corneal epithelial breakdown
Therapeutic Class
- Drugs used for Rheumatoid Arthritis
- Non-Opioid Analgesics
Storage Conditions
- Keep in a dry place away from light and heat
- Keep out of the reach of children