Domin 5 mg/ml (Pediatric Drops)
15 ml drop: ৳ 25.00
Medicine Details
| Category | Details |
|---|---|
| Generic | Domperidone maleate |
| Company | Opsonin pharma ltd |
| Also available as |
Title
- Domperidone 5 mg/ml Drops
Categories
- Medicine
- Pharmaceuticals
- Gastrointestinal
Description
- Dopamine antagonist medication for treating nausea and vomiting
- Motility stimulant/Dopamine antagonist
- Prokinetic drug
Dosage & Administration
- Should be taken 15-30 minutes before meals
- Adults: 10-20 mg every 6-8 hours daily
- Maximum dose is 80 mg daily
Indications
- Dyspeptic symptom complex
- Acute nausea and vomiting
- Parkinson's disease
- Radiological studies
Mechanism of Action
- Blocks dopamine receptors in Chemoreceptor Trigger Zone (CTZ) and stomach
- Restores normal motility and tone of the upper gastrointestinal tract
- Facilitates gastric emptying
Interaction
- Antagonized by anticholinergic drugs
- Lowered oral bioavailability when given with antacids and antisecretory drugs
- Metabolized through CYP3A4 pathway
Contraindications
- Hypersensitivity to domperidone
- Neonates
- Gastrointestinal hemorrhage, mechanical obstruction or perforation
- Prolactin releasing pituitary tumor
Side Effects
- Rare transient intestinal cramps
- Rare extrapyramidal phenomena
- Possible increase in plasma prolactin level
- Rare allergic reactions
Pregnancy & Lactation
- Use during first trimester justified by therapeutic benefit
- Excreted in breast milk but unknown harm to newborns
Precautions & Warnings
- Caution in children due to risk of extra-pyramidal reactions
- Use with caution in hepatic impairment
Use in Special Populations
- Caution in infants due to immature blood-brain barrier
- Caution in hepatic impairment
- Dosage adjustment in severe renal insufficiency
Overdose Effects
- Drowsiness, disorientation, extrapyramidal reactions
- Activated charcoal recommended
- Anticholinergic drugs may help in controlling reactions
Therapeutic Class
- Motility Stimulants
- Dopamine antagonist
- Prokinetic drugs
Storage Conditions
- Store below 30°C
- Protected from light & moisture
- Keep out of children's reach
Chemical Structure
- Molecular Formula: C22H24ClN5O2
- Chemical Structure Image: https://medex.com.bd/storage/res/g-res-380-domperidone-maleate-chemical-structure-4Q6P0Z8laWrV7xnOkSMm.svg
Common Questions
- Used for treating nausea and vomiting
- Should be taken before meals
- May cause dizziness and sleepiness
- Avoid consuming alcohol while taking
- Inform doctor if experiencing certain symptoms