Domin 30 mg (Suppository)

Unit Price: ৳ 8.03 (2 x 5: ৳ 80.30)

Medicine Details

Category Details
Generic Domperidone maleate
Company Opsonin pharma ltd
Also available as
Domin 10 mg tablet Domin 5 mg suspension Domin 5 mg pediatric drop Domin 15 mg suppository

Title

  • Domin 30 mg Suppository

Categories

  • Medicine
  • Healthcare
  • Treatment

Description

  • Domin 30 mg Suppository is a dopamine antagonist medication commonly used to treat a variety of digestive issues, including dyspeptic symptom complex, acute nausea and vomiting, Parkinson's disease-induced nausea and vomiting, and for speeding barium transit in radiological studies.

Dimensions

  • Suppository size: 30 mg

Color Options

  • Not Applicable

Functions

  • Relieve dyspeptic symptom complex
  • Treat acute nausea and vomiting
  • Regulate upper gastrointestinal tract motility
  • Facilitate gastric emptying
  • Enhance antral and duodenal peristalsis
  • Prevent regurgitation of gastric content

Materials

  • Active ingredient: Domperidone
  • Chemical Structure: C22H24ClN5O2

Technical Specifications

  • Molecular Formula: C22H24ClN5O2

Design Elements

  • Chemical structure image available

Usability Features

  • Can be used as a suppository
  • Available in 30 mg dosage

Dosage and Administration

  • Should be taken 15-30 minutes before meals
  • Usual recommended oral dose for adults: 10-20 mg (1-2 tablet or 10-20 ml suspension), every 6-8 hours daily
  • Maximum daily dose for adults: 80 mg

Interactions

  • Antagonized by anticholinergic drugs
  • Should not be given simultaneously with antacids and antisecretory drugs
  • Metabolic pathway through CYP3A4
  • Examples of CYP3A4 inhibitors: azole antifungals, macrolide antibiotics, HIV protease inhibitors, nefazodone
  • May influence the absorption of concomitantly orally administered drugs, particularly those with sustained release or enteric coated formulations
  • Does not potentiate the action of neuroleptics
  • Suppresses unwanted peripheral effects of dopaminergic agonists

Contraindications

  • Known hypersensitivity to Domperidone
  • Neonates
  • Gastrointestinal hemorrhage
  • Mechanical obstruction or perforation
  • Prolactin releasing pituitary tumor (prolactinoma)

Side Effects

  • Transient intestinal cramps
  • Rare extrapyramidal phenomena
  • Increase in plasma prolactin level
  • Rare allergic reactions such as rash and urticaria

Pregnancy and Lactation

  • Use only during the first trimester if justified by anticipated therapeutic benefit
  • Unknown impact on newborns from breast milk
  • Not recommended for nursing mothers unless benefits outweigh potential risk
  • Does not affect mental alertness

Precautions and Warnings

  • Caution in use for children due to increased risk of extra-pyramidal reactions
  • Caution in use for patients with hepatic impairment

Use in Special Populations

  • Caution in use for infants due to incomplete blood-brain barrier development
  • Caution in use for patients with liver disorders
  • Caution in use for patients with severe renal insufficiency

Overdose Effects

  • Symptoms may include drowsiness, disorientation, and extrapyramidal reactions
  • Activated charcoal administration and close patient observation recommended
  • Anticholinergic, antiparkinson drugs, or antihistamines with anticholinergic properties may be helpful

Therapeutic Class

  • Motility Stimulants
  • Dopamine antagonist
  • Prokinetic drugs

Storage Conditions

  • Store below 30°C
  • Protected from light and moisture
  • Keep out of children's reach

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