Emodol 0.5% (Ophthalmic Solution)

5 ml drop: ৳ 70.00

Medicine Details

Category Details
Generic Ketorolac tromethamine
Company Jayson pharmaceuticals ltd
Also available as
Emodol 10 mg tablet Emodol 30 mg injection

Indications

  • Short-term management of moderate to severe acute post-operative pain
  • Relief of pain, inflammation, and light sensitivity after ocular surgery
  • Decrease eye inflammation or redness caused by seasonal allergies

Description

  • Belongs to the pyrrolo-pyrrole group of nonsteroidal anti-inflammatory drug (NSAID)
  • Chemical name: 5 benzoyle-2,3-dihydro-1H-pyrroligine-1-carboxylic acid, compound with 2 - amino-2-(hydroxymethyl)-1,3-propanediol (1:1)
  • Inhibits synthesis of prostaglandins
  • S-form is responsible for biological activity
  • Linear pharmacokinetic property
  • Highly protein bound
  • Largely metabolized in the liver
  • Metabolites and some unchanged drugs are excreted in the urine

Pharmacology

  • Potent analgesic of the non-steroidal anti-inflammatory drugs (NSAIDs)
  • Inhibits the cyclooxygenase enzyme system
  • Demonstrates minimal anti-inflammatory effect at analgesic dose

Dosage & Administration

  • Tablet: Recommended dose is 10 mg every 4-6 hours for short-term use (up to 7 days)
  • Injection: Single or multiple doses for moderately severe, acute pain
  • Administration guidelines for IV and IM dosing based on age, weight, and renal function
  • Maximum daily doses for different patient populations
  • Eye Drops: Recommended dosage is 1 drop in each eye 4 times daily

Interaction

  • Other NSAIDs or aspirin: Increases side effects of Emodol
  • Anti-coagulants: Enhances anti-coagulant effect
  • Beta Blocker: Reduces anti-hypertensive effect
  • ACE Inhibitors: Increases risk of renal impairment
  • Methotrexate: Enhances toxicity of methotrexate

Contraindications

  • Hypersensitivity to Ketorolac or other NSAIDs
  • Children under 16 years of age
  • Prophylactic analgesic before surgery

Side Effects

  • Nausea
  • Vomiting
  • Gastro-intestinal bleeding
  • Melana
  • Peptic ulcer
  • Pancreatitis
  • Anxiety
  • Drowsiness
  • Headache
  • Excessive thirst
  • Fatigue
  • Bradycardia
  • Hypertension
  • Palpitation
  • Chest pain
  • Infertility in females
  • Pulmonary edema

Pregnancy & Lactation

  • US FDA Pregnancy category: C
  • Ketorolac Tromethamine should be avoided in pregnancy and lactation unless benefits outweigh risks to the fetus

Precautions & Warnings

  • Caution in patients over 65 years
  • Caution in patients with active or suspected peptic ulcer, gastrointestinal bleeding, asthma, or liver dysfunction
  • Eye Drops: Discontinue if corneal epithelial breakdown is observed, avoid use with contact lenses

Therapeutic Class

  • Drugs used for Rheumatoid Arthritis
  • Non-Opioid Analgesics

Storage Conditions

  • Keep in a dry place away from light and heat
  • Keep out of the reach of children

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