Emodol 0.5% (Ophthalmic Solution)
5 ml drop: ৳ 70.00
Medicine Details
| Category | Details |
|---|---|
| Generic | Ketorolac tromethamine |
| Company | Jayson pharmaceuticals ltd |
| Also available as |
Indications
- Short-term management of moderate to severe acute post-operative pain
- Relief of pain, inflammation, and light sensitivity after ocular surgery
- Decrease eye inflammation or redness caused by seasonal allergies
Description
- Belongs to the pyrrolo-pyrrole group of nonsteroidal anti-inflammatory drug (NSAID)
- Chemical name: 5 benzoyle-2,3-dihydro-1H-pyrroligine-1-carboxylic acid, compound with 2 - amino-2-(hydroxymethyl)-1,3-propanediol (1:1)
- Inhibits synthesis of prostaglandins
- S-form is responsible for biological activity
- Linear pharmacokinetic property
- Highly protein bound
- Largely metabolized in the liver
- Metabolites and some unchanged drugs are excreted in the urine
Pharmacology
- Potent analgesic of the non-steroidal anti-inflammatory drugs (NSAIDs)
- Inhibits the cyclooxygenase enzyme system
- Demonstrates minimal anti-inflammatory effect at analgesic dose
Dosage & Administration
- Tablet: Recommended dose is 10 mg every 4-6 hours for short-term use (up to 7 days)
- Injection: Single or multiple doses for moderately severe, acute pain
- Administration guidelines for IV and IM dosing based on age, weight, and renal function
- Maximum daily doses for different patient populations
- Eye Drops: Recommended dosage is 1 drop in each eye 4 times daily
Interaction
- Other NSAIDs or aspirin: Increases side effects of Emodol
- Anti-coagulants: Enhances anti-coagulant effect
- Beta Blocker: Reduces anti-hypertensive effect
- ACE Inhibitors: Increases risk of renal impairment
- Methotrexate: Enhances toxicity of methotrexate
Contraindications
- Hypersensitivity to Ketorolac or other NSAIDs
- Children under 16 years of age
- Prophylactic analgesic before surgery
Side Effects
- Nausea
- Vomiting
- Gastro-intestinal bleeding
- Melana
- Peptic ulcer
- Pancreatitis
- Anxiety
- Drowsiness
- Headache
- Excessive thirst
- Fatigue
- Bradycardia
- Hypertension
- Palpitation
- Chest pain
- Infertility in females
- Pulmonary edema
Pregnancy & Lactation
- US FDA Pregnancy category: C
- Ketorolac Tromethamine should be avoided in pregnancy and lactation unless benefits outweigh risks to the fetus
Precautions & Warnings
- Caution in patients over 65 years
- Caution in patients with active or suspected peptic ulcer, gastrointestinal bleeding, asthma, or liver dysfunction
- Eye Drops: Discontinue if corneal epithelial breakdown is observed, avoid use with contact lenses
Therapeutic Class
- Drugs used for Rheumatoid Arthritis
- Non-Opioid Analgesics
Storage Conditions
- Keep in a dry place away from light and heat
- Keep out of the reach of children