Ofpain 0.5% (Ophthalmic Solution)

5 ml drop: ৳ 80.24

Medicine Details

Category Details
Generic Ketorolac tromethamine
Company Kemiko pharmaceuticals ltd
Also available as
Ofpain 10 mg tablet Ofpain 30 mg injection Ofpain 60 mg injection

Indications

  • Short-term management of post-operative pain
  • Relief of pain, inflammation, and light sensitivity after ocular surgery
  • Decreasing eye inflammation or redness caused by seasonal allergies

Description

  • Pyrrolo-pyrrole group nonsteroidal anti-inflammatory drug (NSAID)
  • Chemical structure: 5 benzoyle-2,3-dihydro-1H-pyrroligine-1-carboxylic acid
  • Inhibition of prostaglandin synthesis
  • Metabolized in the liver
  • Highly protein bound

Mode of Action

  • Inhibition of cyclooxygenase enzyme system
  • Minimal anti-inflammatory effect at analgesic dose

Dosage & Administration

  • Tablet recommended dose: 10 mg every 4-6 hours
  • Injection for moderately severe acute pain management
  • Different doses for different age groups and conditions
  • Eye drops: 1 drop in each eye 4 times daily

Interaction

  • Increased side effects with other NSAIDs or aspirin
  • Enhanced anti-coagulant effect with anti-coagulants
  • Reduced anti-hypertensive effect with beta blockers
  • Increased risk of renal impairment with ACE inhibitors
  • Enhanced toxicity of methotrexate

Contraindications

  • Hypersensitivity to Ketorolac or other NSAIDs
  • Children under 16 years of age
  • Prophylactic analgesic use before surgery

Side Effects

  • Nausea
  • Vomiting
  • Gastro-intestinal bleeding
  • Melena
  • Peptic ulcer
  • Pancreatitis
  • Anxiety
  • Drowsiness
  • Headache
  • Excessive thirst
  • Fatigue
  • Bradycardia
  • Hypertension
  • Palpitation
  • Chest pain
  • Female infertility
  • Pulmonary edema

Pregnancy & Lactation

  • FDA Pregnancy category: C
  • Avoid use during pregnancy and lactation unless benefits outweigh risks

Precautions & Warnings

  • Caution in patients over 65 years
  • Caution in patients with peptic ulcer, gastrointestinal bleeding, asthma, or liver dysfunction
  • Discontinue use in case of corneal epithelial breakdown
  • Avoid use with contact lenses

Therapeutic Class

  • Rheumatoid Arthritis drugs
  • Non-Opioid Analgesics

Storage Conditions

  • Keep in a dry place away from light and heat
  • Keep out of reach of children

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