Pair 0.5% (Ophthalmic Solution)

5 ml drop: ৳ 70.25

Medicine Details

Category Details
Generic Ketorolac tromethamine
Company Drug international ltd
Also available as
Pair 10 mg tablet Pair 30 mg injection

Indications

  • Short-term management of moderate to severe acute post-operative pain
  • Relieves pain, inflammation, and light sensitivity after ocular surgery
  • Decreases eye inflammation or redness caused by seasonal allergies

Therapeutic Class

  • Rheumatoid Arthritis
  • Non-Opioid Analgesics

Description

  • Belongs to pyrrolo-pyrrole group of nonsteroidal anti-inflammatory drugs (NSAID)
  • Chemical composition: 5 benzoyle-2,3-dihydro-1H-pyrroligine-1-carboxylic acid, compound with 2 - amino-2-(hydroxymethyl)-1,3-propanediol (1:1)
  • Inhibits synthesis of prostaglandins and acts as a peripherally acting analgesic
  • Pharmacokinetic property is linear
  • Highly protein-bound and largely metabolized in the liver
  • Metabolites and some unchanged drugs are excreted in urine

Mode of Action

  • Potent analgesic of the non-steroidal anti-inflammatory drugs (NSAIDs)
  • Inhibits the cyclooxygenase enzyme system and prostaglandin synthesis
  • Minimal anti-inflammatory effect at analgesic dose

Dosage & Administration

  • Tablet: Recommended dose is 10 mg every 4-6 hours for short-term use (up to 7 days)
  • Tablet: Doses exceeding 40 mg/day is not recommended
  • Injection: Used for the management of moderately severe acute pain, with specific dosage guidelines for different age groups
  • Eye Drops: Recommended dosage is 1 drop in each eye 4 times daily

Interaction

  • Increases side effects with other NSAIDs or aspirin
  • Enhances anti-coagulant effect of anti-coagulants
  • Reduces the anti-hypertensive effect of Beta Blockers
  • Increases the risk of renal impairment with ACE Inhibitors
  • Enhances the toxicity of methotrexate

Contraindications

  • Hypersensitivity to Ketorolac or other NSAIDs
  • Use is contraindicated in children under 16 years of age
  • Contraindicated as prophylactic analgesic before surgery

Side Effects

  • Nausea
  • Vomiting
  • Gastro-intestinal bleeding
  • Melena
  • Peptic ulcer
  • Pancreatitis
  • Anxiety
  • Drowsiness
  • Headache
  • Excessive thirst
  • Fatigue
  • Bradycardia
  • Hypertension
  • Palpitation
  • Chest pain
  • Infertility in females
  • Pulmonary edema

Pregnancy & Lactation

  • US FDA Pregnancy category C
  • Should be avoided in pregnancy and lactation unless benefits outweigh potential risks to the fetus

Precautions & Warnings

  • Exercise caution in patients over 65 years
  • Take caution in patients with active or suspected peptic ulcer, gastrointestinal bleeding, asthma, or liver dysfunction
  • Discontinue use if evidence of corneal epithelial breakdown is found in patients using eye drops

Storage Conditions

  • Keep in a dry place away from light and heat
  • Keep out of the reach of children

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