Recular 0.5% (Ophthalmic Solution)

5 ml drop: ৳ 80.30

Medicine Details

Category Details
Generic Ketorolac tromethamine
Company Reman drug laboratories ltd

Indications

  • Short-term management of post-operative pain
  • Relief of ocular surgery-related pain and inflammation
  • Reduction of eye inflammation caused by seasonal allergies

Description

  • Pyrrolo-pyrrole group of NSAID
  • Chemical name: 5 benzoyle-2,3-dihydro-1H-pyrroligine-1-carboxylic acid, compound with 2 - amino-2-(hydroxymethyl)-1,3-propanediol (1:1)
  • Inhibition of prostaglandin synthesis
  • Biologically active S-form
  • Linear pharmacokinetic property
  • Highly protein bound
  • Mainly metabolized in liver
  • Metabolites and unchanged drug excretion in urine

Pharmacology

  • Potent analgesic NSAID
  • Inhibits cyclooxygenase enzyme system and prostaglandin synthesis
  • Minimal anti-inflammatory effect at analgesic dose

Dosage & Administration

  • Tablet: Recommended dose is 10 mg every 4-6 hours for up to 7 days
  • Injection: Single or multiple doses for acute pain management with specific dosing guidelines for different age groups and conditions
  • Eye Drops: Recommended dosing regimen for adults

Interaction

  • Increased side effects with other NSAIDs or aspirin
  • Enhanced anti-coagulant effect with anti-coagulants
  • Reduced anti-hypertensive effect with Beta Blockers
  • Increased risk of renal impairment with ACE Inhibitors
  • Enhanced toxicity of methotrexate

Contraindications

  • Hypersensitivity to Ketorolac or other NSAIDs
  • Not for use in children under 16 years
  • Contraindicated as prophylactic analgesic before surgery

Side Effects

  • Nausea
  • Vomiting
  • Gastro-intestinal bleeding
  • Melana
  • Peptic ulcer
  • Pancreatitis
  • Anxiety
  • Drowsiness
  • Headache
  • Excessive thirst
  • Fatigue
  • Bradycardia
  • Hypertension
  • Palpitation
  • Chest pain
  • Infertility in females
  • Pulmonary edema

Pregnancy & Lactation

  • FDA Pregnancy category C
  • Avoid use in pregnancy and lactation unless benefits outweigh risks

Precautions & Warnings

  • Caution in patients over 65 years
  • Caution in patients with peptic ulcer, gastrointestinal bleeding, asthma, or liver dysfunction
  • Discontinue use and monitor corneal health in patients with corneal epithelial breakdown
  • Avoid administration while wearing contact lenses

Therapeutic Class

  • Rheumatoid Arthritis
  • Non-Opioid Analgesics

Storage Conditions

  • Keep in a dry place away from light and heat
  • Keep out of the reach of children

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