Dominol 10 mg (Tablet)
Unit Price: ৳ 2.50 (100's pack: ৳ 250.00)
Medicine Details
| Category | Details |
|---|---|
| Generic | Domperidone maleate |
| Company | The white horse pharmaceuticals ltd |
Title and Categories
- Dominol 10 mg Tablet
- Medicine
- Pharmaceutical
Indications
- Dyspeptic symptom complex
- Delayed gastric emptying
- Gastroesophageal reflux
- Esophagitis
- Epigastric sense of fullness
- Feeling of abdominal distension
- Upper abdominal pain
- Eructation
- Flatulence
- Early satiety
- Nausea
- Vomiting
- Heartburn
- Non-ulcer dyspepsia
- Acute nausea
- Vomiting of functional, organic, infectious, dietetic origin
- Vomiting induced by radiotherapy or drug therapy
- Vomiting induced in migraine
- Parkinson's disease
- Dopamine-agonist induced nausea and vomiting
- Radiological studies
- Barium transit in follow-through radiological studies
Pharmacology
- Dopamine antagonist
- Blocks dopamine receptors in Chemoreceptor Trigger Zone (CTZ) and stomach
- Gastroprokinetic action
- Enhances antral and duodenal peristalsis
- Regulates contraction of the pylorus
- Increases esophageal peristalsis
- Increases lower esophageal sphincter pressure
Dosage & Administration
- To be taken 15-30 minutes before meals
- Adults: 10-20 mg every 6-8 hours daily
- Children: 2-4 ml suspension/10 kg body weight
- Acute and sub-acute conditions: 20 mg every 6-8 hours daily
- Rectal administration for adults and children
- Maximum dose of 80 mg daily
Interaction
- Anticholinergic drugs antagonize antidyspeptic effect
- Lower oral bioavailability with antacids and antisecretory drugs
- Main metabolic pathway through CYP3A4
- In vitro data suggests drug interactions with CYP3A4 inhibitors
- Does not influence the action of neuroleptics
- Suppresses unwanted peripheral effects of dopaminergic agonists
Contraindications
- Known hypersensitivity
- Neonates
- Gastrointestinal stimulation might be dangerous
- Prolactin releasing pituitary tumor (prolactinoma)
Side Effects
- Transient intestinal cramps
- Rare extrapyramidal phenomena
- Increase in plasma prolactin level
- Rare allergic reactions like rash and urticaria
Pregnancy & Lactation
- Use during first trimester if justified by therapeutic benefit
- No evidence of increase in risk of malformations
- Excreted in breast milk
- Concentrations in breast milk lower than plasma
- Effects on driving and machine use
Precautions & Warnings
- Increased risk of extra-pyramidal reactions in young children
- Highly metabolized in the liver
- Caution in hepatic impairment
Use in Special Populations
- Infants: Caution due to incomplete development of blood-brain barrier
- Liver disorders
- Kidney disorders
Overdose Effects
- Drowsiness
- Disorientation
- Extrapyramidal reactions
- Activated charcoal administration recommended
Therapeutic Class
- Motility Stimulants
- Dopamine antagonist
- Prokinetic drugs
Storage Conditions
- Store below 30°C
- Protected from light & moisture
- Keep out of children's reach
Chemical Structure
- Molecular Formula: C22H24ClN5O2
Common Questions
- Usage for treating nausea and vomiting
- Relieves nausea, vomiting, and indigestion
- Caution in driving and alcohol consumption