Neosuxa 100 mg/2 ml (IM/IV Injection)

Indications

• Facilitate endotracheal intubation
• Aid in mechanical ventilation
• Assist a wide range of surgical and obstetric procedures

Pharmacology

• Acts as a depolarizing neuromuscular blocker
• Imitates the action of acetylcholine at the neuromuscular junction
• Acts on muscle type nicotinic receptors
• Results in opening of the receptor's nicotinic sodium channel
• Causes fasciculation
• Has a longer duration of effect than acetylcholine

Dosage & Administration

• Usually administered by bolus intravenous or intramuscular injection
• Dose dependent on body weight
• Produces muscular relaxation in about 30-60 seconds
• Duration of action of about 2-6 minutes
• Infants and young children are more resistant to Suxamethonium compared with adults

Interaction

• Certain drugs or chemicals known to reduce normal plasma cholinesterase activity may prolong the neuromuscular blocking effects
• Includes trimetaphan, specific anticholinesterase agents, cytotoxic compounds, psychiatric drugs, anesthetic agents, and drugs

Contraindications

• Should not be administered to a patient who is not fully anesthetized
• Not to be given to patients known to be hypersensitive to the drug
• Is contraindicated in patients with inherited atypical plasma cholinesterase activity
• Should not be used in the presence of open eye injuries
• Contraindicated in new-born infants, especially in immature neonates

Side Effects

• Cardiovascular effects like bradycardia, tachycardia, hypertension, hypotension, and arrhythmias
• Respiratory effects like bronchospasm, prolonged respiratory depression, and apnea
• Musculoskeletal effects like muscle fasciculation, post-operative muscle pains, and myoglobinemia
• Other effects like hyperthermia, increased intra-ocular pressure, increased intra-gastric pressure, rash, and excessive salivation

Pregnancy & Lactation

• Does not readily cross the placental barrier but should not be administered to pregnant women unless the potential benefit outweighs possible hazards

Precautions & Warnings

• Should be administered only by or under close supervision of an anesthetist familiar with its action and characteristics
• Skilled in the management of artificial respiration and only where there are adequate facilities for immediate endotracheal intubation with administration of oxygen by intermittent positive pressure ventilation
• Elderly may be more susceptible to cardiac arrhythmias, especially if digitalis-like drugs are also being taken

Therapeutic Class

• Depolarizing muscle relaxants

Storage Conditions

• Store in a refrigerator between 2°C-8°C
• Do not freeze

Related Brands

• G-Suxamethonium 100 mg/2 ml (IM/IV Injection) - gonoshasthaya-pharma-ltd
• Suxa 100 mg/2 ml (IM/IV Injection) - chemist-laboratories-ltd
• Suxonium 100 mg/2 ml (IM/IV Injection) - techno-drugs-ltd