Suxa 100 mg/2 ml (IM/IV Injection)

2 ml ampoule: ৳ 8.30 (1 x 5: ৳ 41.50)

Medicine Details

Category Details
Generic Suxamethonium chloride
Company Chemist laboratories ltd

Indications

  • Facilitate endotracheal intubation
  • Aid in mechanical ventilation
  • Assist in a wide range of surgical and obstetric procedures

Pharmacology

  • Depolarizing neuromuscular blocking agent
  • Imitates the action of acetylcholine at the neuromuscular junction
  • Acts on muscle type nicotinic receptors
  • Results in opening of the receptor's nicotinic sodium channel
  • Leads to calcium release from the sarcoplasmic reticulum
  • Results in muscle relaxant effects

Dosage & Administration

  • Administered by bolus Intravenous or Intramuscular injection
  • Adult dosage dependent on body weight and response
  • Children more resistant compared to adults
  • Total dose given should not exceed 500 mg per hour
  • Administered as intravenous infusion for prolonged surgical procedures

Interaction

  • Certain drugs may prolong the neuromuscular blocking effects
  • Drugs include specific anticholinesterase agents, cytotoxic compounds, psychiatric drugs, anesthetic agents and drugs

Contraindications

  • Not to be administered to patients who are not fully anesthetized
  • Contraindicated in patients known to have an inherited atypical plasma cholinesterase activity
  • Contraindicated in patients recovering from major trauma or severe burns
  • Avoid use in patients with pre-existing hyperkalemia
  • Not to be used in the presence of open eye injuries
  • Contraindicated in newborn infants

Side Effects

  • Cardiovascular effects include bradycardia, tachycardia, hypertension, hypotension, arrhythmias
  • Respiratory effects include bronchospasm, prolonged respiratory depression and apnea
  • Musculoskeletal effects include muscle fasciculation, post-operative muscle pains, myoglobinemia
  • Other effects include hyperthermia, increased intra-ocular pressure, increased intra-gastric pressure, rash, excessive salivation

Pregnancy & Lactation

  • Should not be administered to pregnant women unless potential benefit outweighs possible hazards

Precautions & Warnings

  • Should be administered by or under close supervision of an anesthetist familiar with its action
  • Elderly may be more susceptible to cardiac arrhythmias

Therapeutic Class

  • Depolarizing muscle relaxants

Storage Conditions

  • Store in a refrigerator between 2°C-8°C
  • Do not freeze

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