Stigmin 0.5 mg/ml (Injection)
1 ml ampoule: ৳ 7.00 (2 x 5: ৳ 70.00)
Medicine Details
| Category | Details |
|---|---|
| Generic | Neostigmine methylsulphate |
| Company | Techno drugs ltd |
Indications
- Symptomatic control of myasthenia gravis
- Prevention and treatment of postoperative distention and urinary retention
- Reversal of effects of nondepolarizing neuromuscular blocking agents
Pharmacology
- Anticholinesterase agent
- Sterile, nonpyrogenic solution
- Intramuscular (IM), intravenous (IV), or subcutaneous (SC) administration
- Parasympathomimetic
- Reversible cholinesterase inhibitor
- Inhibition of acetylcholinesterase
- Stimulation of nicotinic and muscarinic receptors
Dosage & Administration
- Adult dosage
- Children dosage
- Myasthenia gravis dosage for adults and neonates
- Urinary retention dosage for prophylaxis and treatment
Interaction
- Interaction with depolarizing muscle relaxants
- Potential interactions with antibiotics, anesthetics, antiarrhythmic agents
- Careful adjustment of anticholinesterase dosage
Contraindications
- Known hypersensitivity to the drug
- Peritonitis
- Mechanical obstruction of the intestinal or urinary tract
Side Effects
- Cardiovascular adverse reactions
- Central Nervous System adverse reactions
- Gastrointestinal adverse reactions
- Genitourinary adverse reactions
- Musculoskeletal adverse reactions
- Respiratory adverse reactions
- Allergic reactions
- Skin reactions
- Others: increased sweating and salivation, miosis, vision changes, nystagmus, lacrimation
Pregnancy & Lactation
- Pregnancy category C
- Nonteratogenic effects
- Use in lactation
Precautions & Warnings
- Use with caution in patients with epilepsy, bronchial asthma, bradycardia, recent coronary occlusion, vagotonia, hyperthyroidism, cardiac arrhythmias, or peptic ulcer
- Possibility of hypersensitivity in an occasional patient
- Readily available atropine and antishock medication
Overdose Effects
- Cholinergic crisis
- Respiratory paralysis
- Differentiation from myasthenic crisis
- Use of edrophonium and clinical judgement for differentiation
Therapeutic Class
- Anti-cholinesterases
- Drugs used in Myasthenia Gravis
Storage Conditions
- Store at controlled room temperature
- Protected from light
- Discard remaining contents