Dompa-S 5 mg/5 ml (Oral Suspension)
60 ml bottle: ৳ 28.00
Medicine Details
| Category | Details |
|---|---|
| Generic | Domperidone maleate |
| Company | Seema pharmaceuticals ltd |
| Also available as |
Indications
- Delayed gastric emptying
- Gastroesophageal reflux
- Esophagitis
- Epigastric sense of fullness
- Abdominal distension
- Upper abdominal pain
- Eructation
- Flatulence
- Early satiety
- Nausea
- Vomiting
- Heartburn
- Migraine-induced nausea and vomiting
- Parkinson's disease-induced nausea and vomiting
- Speeding barium transit in radiological studies
Pharmacology
- Dopamine antagonist
- Blocks dopamine receptors in the Chemoreceptor Trigger Zone (CTZ)
- Gastroprokinetic action
- Restores normal motility and tone of the upper gastrointestinal tract
- Facilitates gastric emptying
- Enhances antral and duodenal peristalsis
- Regulates contraction of the pylorus
- Increases esophageal peristalsis
- Regulates lower esophageal sphincter pressure
Dosage & Administration
- Should be taken 15-30 minutes before meals
- Adult dose: 10-20 mg every 6-8 hours daily
- Maximum adult dose: 80 mg daily
- Children's dose based on body weight
- Suppositories for adults and children
- Acute and sub-acute conditions dosing
- Rectal administration dosing
Interaction
- Concomitant administration of anticholinergic drugs may antagonize the effect
- Antacids and antisecretory drugs lower oral bioavailability
- Metabolic pathway through CYP3A4
- In vitro data on CYP3A4 inhibitors
- Potential influence on the absorption of concomitantly orally administered drugs
- Neuroleptics action
- Action on dopaminergic agonists
Contraindications
- Known hypersensitivity to the drug
- Neonates
- Gastrointestinal hemorrhage
- Mechanical obstruction
- Perforation
- Prolactin releasing pituitary tumor (prolactinoma)
Side Effects
- Transient intestinal cramps
- Extrapyramidal phenomena
- Increased plasma prolactin level
- Neuroendocrinological phenomena
- Allergic reactions such as rash and urticaria
Pregnancy & Lactation
- Use in first trimester if justified
- No evidence of increase in the risk of malformations in humans
- Excreted in breast milk of lactating rats
- Concentrations in breast milk are 4 times lower than plasma concentrations
Precautions & Warnings
- Caution in the case of children
- Increased risk of extra-pyramidal reactions in young children
- Use with caution in patients with hepatic impairment
Use in Special Populations
- Caution in infants due to immature blood-brain barrier
- Use in liver disorders
- Use in kidney disorders
Overdose Effects
- Symptoms include drowsiness, disorientation, and extrapyramidal reactions
- Recommendations for managing the overdose
Therapeutic Class
- Motility Stimulants
- Dopamine antagonist
- Prokinetic drugs
Storage Conditions
- Store below 30°C
- Protected from light & moisture
- Keep out of children's reach
Chemical Structure
- Molecular Formula: C22H24ClN5O2
- Chemical Structure Image
Common Questions about Dompa-S 5 mg/5 ml Suspension
- Usage for treating nausea and vomiting
- Quick tips for taking the suspension