Dixicon 300 mg/5 ml (Oral Suspension)
50 ml bottle: ৳ 30.54
Medicine Details
| Category | Details |
|---|---|
| Generic | Nalidixic acid |
| Company | Jayson pharmaceuticals ltd |
Indications
- Treatment of urinary tract infection
- Susceptible Gram-negative organisms
- Proteus species
- Klebsiella species
- Enterobacter species
- Escherichia coli
Pharmacology
- Synthetic narrow spectrum antibacterial
- Bacteriostatic or bactericidal
- Inhibits bacterial DNA synthesis
- Interferes with DNA polymerization
- Rapid and complete absorption from G.I. Tract
- Distribution to most tissues
- Rapid and almost complete excretion within 24 hours
Dosage & Administration
- Adult dosage: initially 1g every 6 hours for 7 days reducing to 500 mg every 6 hours
- Children dosage: Oral 13.75 mg per kg body weight every six hours for one or two weeks
Interaction
- Concomitant use with melphalan
- Reports of death from severe blood-containing diarrhoea caused by hemorrhagic ulcerative colitis
- Probenecid inhibits tubular secretion and may elevate serum concentration
- Potentiation of effect by Chlorpromazine and Perphenazine
Contraindications
- Infants under 3 months
- Epilepsy
- CNS lesions
Side Effects
- Gastro-intestinal disturbances
- Nausea
- Vomiting
- Diarrhoea
- Haemolysis in G6PD deficiency
- Allergic reactions
- Urticaria
- Rashes
- Fever
- Arthralgia
- Eosinophilia
- Myalgia
- Muscle weakness
- Phototoxicity
- Jaundice
- Visual disturbances
- Convulsions
Pregnancy & Lactation
- Possibility of causing cartilage damage
- Possibility of causing DNA damage
- Excretion in breast milk
- Report of hemolytic anaemia in breastfed child of an azotemic mother
Precautions & Warnings
- Risk-benefit considerations during the first trimester of pregnancy
- Risk-benefit considerations during breastfeeding
- Impaired renal or hepatic function
Therapeutic Class
- Anti-diarrhoeal
- Antimicrobial drugs
- Anti-protozoals
- Systemic Urinary Anti-infective
Storage Conditions
- Keep below 30°C temperature
- Away from light & moisture
- Keep out of the reach of children
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