Dixicon 300 mg/5 ml (Oral Suspension)

Indications

• Treatment of urinary tract infection
• Susceptible Gram-negative organisms
• Proteus species
• Klebsiella species
• Enterobacter species
• Escherichia coli

Pharmacology

• Synthetic narrow spectrum antibacterial
• Bacteriostatic or bactericidal
• Inhibits bacterial DNA synthesis
• Interferes with DNA polymerization
• Rapid and complete absorption from G.I. Tract
• Distribution to most tissues
• Rapid and almost complete excretion within 24 hours

Dosage & Administration

• Adult dosage: initially 1g every 6 hours for 7 days reducing to 500 mg every 6 hours
• Children dosage: Oral 13.75 mg per kg body weight every six hours for one or two weeks

Interaction

• Concomitant use with melphalan
• Reports of death from severe blood-containing diarrhoea caused by hemorrhagic ulcerative colitis
• Probenecid inhibits tubular secretion and may elevate serum concentration
• Potentiation of effect by Chlorpromazine and Perphenazine

Contraindications

• Infants under 3 months
• Epilepsy
• CNS lesions

Side Effects

• Gastro-intestinal disturbances
• Nausea
• Vomiting
• Diarrhoea
• Haemolysis in G6PD deficiency
• Allergic reactions
• Urticaria
• Rashes
• Fever
• Arthralgia
• Eosinophilia
• Myalgia
• Muscle weakness
• Phototoxicity
• Jaundice
• Visual disturbances
• Convulsions

Pregnancy & Lactation

• Possibility of causing cartilage damage
• Possibility of causing DNA damage
• Excretion in breast milk
• Report of hemolytic anaemia in breastfed child of an azotemic mother

Precautions & Warnings

• Risk-benefit considerations during the first trimester of pregnancy
• Risk-benefit considerations during breastfeeding
• Impaired renal or hepatic function

Therapeutic Class

• Anti-diarrhoeal
• Antimicrobial drugs
• Anti-protozoals
• Systemic Urinary Anti-infective

Storage Conditions

• Keep below 30°C temperature
• Away from light & moisture
• Keep out of the reach of children

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