Domsil 10 mg (Tablet)
Unit Price: ৳ 2.30 (10 x 10: ৳ 230.00)
Strip Price: ৳ 23.00
Medicine Details
| Category | Details |
|---|---|
| Generic | Domperidone maleate |
| Company | Silva pharmaceuticals ltd |
| Also available as |
Title
- Domsil 10 mg Tablet
Category
- Medicine
- Healthcare
- Pharmaceutical
Indications
- Dyspeptic symptom complex
- Delayed gastric emptying
- Gastroesophageal reflux
- Esophagitis
- Acute nausea and vomiting
- Functional nausea and vomiting
- Nausea and vomiting induced by radiotherapy
- Nausea and vomiting induced by drug therapy
- Nausea and vomiting induced in migraine
- Parkinson's disease
- Radiological studies
Pharmacology
- Dopamine antagonist
- Blocks dopamine receptors in Chemoreceptor Trigger Zone and stomach
- Gastroprokinetic action
- Restores normal motility and tone of upper gastrointestinal tract
- Facilitates gastric emptying
- Enhances antral and duodenal peristalsis
- Regulates contraction of the pylorus
- Increases esophageal peristalsis
- Regulates lower esophageal sphincter pressure
Dosage & Administration
- Should be taken 15-30 minutes before meals
- Adults dose: 10-20 mg every 6-8 hours daily, maximum 80 mg daily
- Children dose: 2-4 ml suspension/10 kg body weight every 6-8 hours daily
- Acute nausea and vomiting adult dose: 20 mg every 6-8 hours daily
- By rectum in suppositories for adults and children
Interaction
- Anticholinergic drugs may antagonize the antidyspeptic effect
- Avoid simultaneous administration with antacids and antisecretory drugs
- Metabolized through CYP3A4 pathway
- Concomitant use of CYP3A4 inhibitors may increase plasma levels
- Possible influence on absorption of concomitantly orally administered drugs
- Does not potentiate the action of neuroleptics
- Suppresses unwanted peripheral effects of dopaminergic agonists
Contraindications
- Known hypersensitivity to the drug
- Neonates
- Gastrointestinal hemorrhage
- Mechanical obstruction or perforation
- Prolactin releasing pituitary tumor
Side Effects
- Transient intestinal cramps
- Rare extrapyramidal phenomena
- Increase in plasma prolactin level
- Rare allergic reactions
- Possible neuroendocrinological phenomena
Pregnancy & Lactation
- Caution during first trimester of pregnancy
- Potential excretion in breast milk
- Lower concentrations in breast milk compared to plasma
Precautions & Warnings
- Absolute caution in the case of children
- Increased risk of extrapyramidal reactions in young children
- Caution in patients with hepatic impairment
Use in Special Populations
- Caution in infants due to underdeveloped blood-brain barrier
- Caution in patients with hepatic impairment
- Effect on dosing frequency in patients with severe renal insufficiency
Overdose Effects
- Symptoms may include drowsiness, disorientation, and extrapyramidal reactions
- Administration of activated charcoal recommended
- Anticholinergic or antiparkinson drugs may be helpful in controlling the reactions
Therapeutic Class
- Motility Stimulants
- Dopamine antagonist
- Prokinetic drugs
Storage Conditions
- Store below 30°C
- Protected from light & moisture
- Keep out of children's reach
Chemical Structure
- Molecular Formula: C22H24ClN5O2
Common Questions
- Used to treat nausea and vomiting
- Relieves nausea, vomiting, and indigestion
- May cause dizziness and sleepiness
- Avoid consuming alcohol during treatment
- Dry mouth may occur as a side effect
- Inform your doctor of certain symptoms
- Do not take for longer than 7 days without consulting your doctor