Tamfast 0.4 mg (Capsule (Modified Release))

Unit Price: ৳ 10.03 (3 x 10: ৳ 300.90)

Strip Price: ৳ 100.30

Medicine Details

Category	Details
Generic	Tamsulosin hydrochloride
Company	Radiant pharmaceuticals ltd
Also available as	Mictrol 04 mg capsule

Title

Tamfast Hydrochloride Capsules

Description

Tamsulosin Hydrochloride capsules for the treatment of functional symptoms of Benign Prostatic Hyperplasia (BPH)

Color Options

White

Dosage Form

Capsule

Dosage Strengths

0.4mg
0.8mg

Dosage Instructions

Take 1 capsule daily after a meal at night
May increase to 2 capsules daily after 2 to 4 weeks if necessary

Administration Method

Oral, Swallow whole with a glass of water

Contraindications

Hypersensitivity to Tamsulosin hydrochloride
History of orthostatic hypotension
Severe hepatic insufficiency

Indications

Treatment of symptoms of Benign Prostatic Hyperplasia (BPH)

Pharmacology

Selective alpha1 adrenoceptor blocking agent
Relaxes smooth muscle in bladder neck and prostate
Improvement in urine flow rate
Reduction in symptoms of BPH

Absorption

Essentially complete (90%) following oral administration under fasting conditions

Time to Maximum Concentration

4-5 hours under fasting conditions
6-7 hours when administered with food

Plasma Protein Binding

94% to 99%

Metabolism

Extensively metabolized by cytochrome P450 enzymes in the liver

Elimination Half-life

5-7 hours in plasma
Approximately 9-13 hours in healthy volunteers
14-15 hours in the target population

Interactions

Concomitant use of other alfa1-adrenoceptor antagonists
No interactions observed with atenolol, enalapril, or nifedipine
Concurrent cimetidine may raise plasma levels, frusemide may lower plasma levels
No interactions at the level of hepatic metabolism with selected drugs
Diclofenac and warfarin may increase the elimination rate

Side Effects

Dizziness
Abnormal ejaculation
Headache
Asthenia
Postural hypotension
Palpitations

Pregnancy & Lactation

Not recommended for use during pregnancy and lactation

Precautions & Warnings

Rare transient postural symptoms may occur
Use in patients with micturition syncope is not advised
Effect on ability to drive and use machines is not fully studied

Overdose Effects

Acute hypotension likely to occur
Cardiovascular support should be given
Renal function monitoring and general supportive measures should be applied
Gastric lavage and activated charcoal may be administered in case of acute overdosage