Prostam 0.4 mg (Capsule (Modified Release))

Unit Price: ৳ 10.05 (3 x 10: ৳ 301.50)

Strip Price: ৳ 100.50

Medicine Details

Category	Details
Generic	Tamsulosin hydrochloride
Company	Drug international ltd

Selective alpha1 adrenoceptor blocking agent
Relaxes smooth muscle in the bladder neck and prostate
Improves urine flow rate
Reduces symptoms of BPH
Complete absorption (90%) following oral administration under fasting conditions
Time to maximum concentration (Tmax) reached by four to five hours under fasting conditions
Extensively metabolized by cytochrome P 450 enzymes in the liver
Elimination half-life of Tamsulosin hydrochloride ranges from five to seven hours
Apparent half-life of Tamsulosin hydrochloride is approximately 9 to 15 hours

Tamsulosin Hydrochloride 0.4mg (one capsule) daily
May be increased to Tamsulosin Hydrochloride 0.8mg (two capsules) once daily if necessary
To be taken after meal at night
Capsule should be swallowed whole with a glass of water (about 150ml) in standing or sitting position

Concurrent administration of other alfa1-adrenoceptor antagonists could lead to hypotensive effects
No interactions seen with atenolol, enalapril, or nifedipine
Cimetidine may increase plasma levels
Frusemide may decrease plasma levels
No interactions at the level of hepatic metabolism during in vitro studies with certain drugs
Diclofenac and warfarin may increase the elimination rate

Hypersensitivity to Tamsulosin hydrochloride
History of orthostatic hypotension
Severe hepatic insufficiency
Potential reduction in blood pressure and risk of syncope
Sit or lie down at first signs of orthostatic hypotension
Examination to exclude other conditions before therapy initiation
Regular examinations including digital rectal examination and Prostate Specific Antigen (PSA) determination

Transient postural symptoms rarely occurred during orthostatic provocation testing after the first dose
Use not advised in patients with micturition syncope
Effect on ability to drive and use machines is not fully known