Prostanil MR 0.4 mg (Capsule (Modified Release))
Unit Price: ৳ 10.00 (5 x 6: ৳ 300.00)
Strip Price: ৳ 60.00
Medicine Details
| Category | Details |
|---|---|
| Generic | Tamsulosin hydrochloride |
| Company | Aristopharma ltd |
Therapeutic Class
- BPH/ Urinary retention/ Urinary incontinence
Indications
- Treatment of functional symptoms of Benign Prostatic Hyperplasia (BPH)
Pharmacology
- Selective alpha1 adrenoceptor blocking agent
- Relaxes smooth muscle in bladder neck and prostate
- Improvement in urine flow rate
- Reduction in symptoms of BPH
- Absorption rate under fasting and fed conditions
- Plasma protein binding
- Metabolism by cytochrome P 450 enzymes
- Elimination half-life
- Apparent half-life in healthy volunteers and target population
Dosage & Administration
- Tamsulosin Hydrochloride 0.4 mg daily
- Tamsulosin Hydrochloride 0.8 mg after 2 to 4 weeks if necessary
- Administration after meal at night
- Swallowing capsule whole with water
- No crunching or chewing
Interaction
- Concurrent administration with alpha1-adrenoceptor antagonists
- No interaction with atenolol, enalapril, nifedipine
- Cimetidine and frusemide effects on plasma levels
- No interactions at the level of hepatic metabolism
- Effect on elimination rate with diclofenac and warfarin
Contraindications
- Hypersensitivity
- Orthostatic hypotension
- Severe hepatic insufficiency
- Reduction in blood pressure
- Orthostatic hypotension
- Syncope
- Digital rectal examination before treatment
- Prostate Specific Antigen (PSA) determination
Side Effects
- Dizziness
- Abnormal ejaculation
- Headache
- Asthenia
- Postural hypotension
- Palpitations
Pregnancy & Lactation
- Not recommended
Precautions & Warnings
- Transient postural symptoms
- Use in patients with micturition syncope not advised
- No data available on effects on ability to drive or operate machines
- Dizziness can occur
Overdose Effects
- Acute hypotension likely
- Cardiovascular support
- Monitoring of renal function
- General supportive measures
- Gastric lavage and activated charcoal
- Dialysis unlikely to be helpful
Storage Conditions
- Store below 30°C
- Cool and dry place
- Protected from light
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