Tamisol MR 0.4 mg (Capsule (Modified Release))

Unit Price: ৳ 10.00 (5 x 6: ৳ 300.00)
Strip Price: ৳ 60.00

Medicine Details

Category Details
Generic Tamsulosin hydrochloride
Company Healthcare pharmaceuticals ltd

Indications

  • Treatment of functional symptoms of Benign Prostatic Hyperplasia (BPH)

Pharmacology

  • Selective alpha1 adrenoceptor blocking agent
  • Relaxes smooth muscle in the bladder neck and prostate
  • Improves urine flow rate
  • Reduces symptoms of BPH
  • Complete absorption (90%) under fasting conditions
  • High plasma protein binding (94% to 99%)
  • Extensive metabolism by cytochrome P450 enzymes
  • Elimination half-life ranges from five to seven hours
  • Apparent half-life of approximately 9 to 15 hours

Dosage & Administration

  • Tamsulosin Hydrochloride 0.4 mg (one capsule) daily
  • To be taken after meal at night
  • Dose may be increased to 0.8 mg once daily if necessary
  • Capsule should be swallowed whole with a glass of water
  • Should not be crunched or chewed

Interaction

  • Concurrent administration with other alfa1-adrenoceptor antagonists could lead to hypotensive effects
  • No interactions seen with atenolol, enalapril, or nifedipine
  • Concomitant cimetidine raises plasma levels, frusemide lowers plasma levels
  • No interactions at the level of hepatic metabolism seen during in vitro studies

Contraindications

  • Hypersensitivity to Tamsulosin hydrochloride
  • History of orthostatic hypotension
  • Severe hepatic insufficiency
  • Reduction in blood pressure can occur
  • Caution with orthostatic hypotension
  • Patient examination is advised before therapy initiation

Side Effects

  • Dizziness
  • Abnormal ejaculation
  • Headache
  • Asthenia
  • Postural hypotension
  • Palpitations

Pregnancy & Lactation

  • Not recommended for use

Precautions & Warnings

  • Transient postural symptoms may occur
  • Use in patients with micturition syncope not advised
  • Effects on ability to drive and use machines uncertain
  • Patients should be aware of the potential for dizziness

Overdose Effects

  • No reported cases of acute overdosage
  • Acute hypotension likely in case of overdosage
  • Cardiovascular support should be given
  • Volume expanders and vasopressors may be required
  • Renal function should be monitored
  • General supportive measures should be applied
  • Gastric lavage and administration of activated charcoal and osmotic laxative may be necessary

Therapeutic Class

  • BPH/Urinary retention/Urinary incontinence

Storage Conditions

  • Store in a cool and dry place below 30°C
  • Protected from light

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